Publications by authors named "Fattin Wekselman"
Background: Lewy body disease (LBD) often co-occurs with Alzheimer's (AD), resulting in more significant cognitive decline than AD or LBD alone. LBD's hallmarks, asyn-positive Lewy bodies and neurites, propagate from the enteric system or olfactory bulb to the amygdala, which acts as a gatekeeper for spread to other structures. Initially, LBD appears in the central or cortical nuclei, reflecting brainstem or olfactory origins.
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- Lewy body disease (LBD) is involved in various neurodegenerative syndromes, and the αSyn-SAA assay shows excellent sensitivity and specificity for diagnosing cortical LBD cases.
- However, the assay has lower sensitivity in amygdala-predominant and brainstem-predominant LBD cases, though positive results may indicate early disease progression.
- Overall, the αSyn-SAA assay offers precise diagnosis of LBD and may help identify co-pathologies, which could influence treatment outcomes and aid in clinical trials.