Publications by authors named "Fattaneh Farifteh Nobijari"
Objective: maturation (IVM) of human oocytes is used to induce meiosis progression in immature retrieved oocytes. Calcium (Ca) has a central role in oocyte physiology. Passage through meiosis phase to another phase is controlled by increasing intracellular Ca.
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- About 10% of infertile patients experience repeated implantation failures (RIFs) during IVF treatments, making successful implantation reliant on immune responses.
- A study with 250 couples tested the effects of cultured peripheral blood mononuclear cells (PBMCs) on pregnancy outcomes after embryo transfer, revealing a higher clinical pregnancy rate in the PBMC group (34.4%) compared to the control (23.4%), although not statistically significant overall.
- In patients with three or more RIFs, there was a significant improvement in clinical pregnancy rates for the PBMC group (38.6%) versus the control (19.7%), suggesting PBMC transfer could enhance fertility treatment for these patients.
Objectives: We evaluated the effect of melatonin, as a potent antioxidant agent, on glutathione (GSH) and reactive oxygen species (ROS) levels, as well as histone H3 lysine 9 (H3K9), and H4 lysine 12 (H4K12) acetylation when added to oocytes culture medium.
Materials And Methods: In this experimental study, two in vitro and in vivo groups were used. In the in vitro group, cumulus oocyte complexes (COCs) from the ovaries of B6D2F1 mice were cultured in maturation medium containing two doses of melatonin (10 and 10 M) and without melatonin [control group treated with dimethyl sulfoxide (DMSO)] for 22-24 hour.
There is growing evidence that the spermatozoon's epigenetic structure is of the utmost importance in the health of the future embryo. Following fertilization, sperm chromatin undergoes epigenetic reprogramming including DNA demethylation and remethylation, which resets gene expression. In some infertile patients, it is inevitable that sperm cells that are not within the range of normal human sperm parameters will be used for intracytoplasmic sperm injection.
View Article and Find Full Text PDFEpigenetic abnormalities and abnormal chromatin structure in sperm may lead to male infertility. Protamine deficiency is among the disorders of chromatin structure in sperm. The study of epigenetic changes in male pronuclei is necessary since abnormal sperm is sometimes used to create embryos using assisted reproductive techniques.
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