High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones.

Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering.

Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T-weighted MR imaging capability.

The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40-55nm sized silica spheres.

[Human and animal cells adhesion on the modified glass].

2D matrix for cells cultivation has been created using ionic plasma processing of silicate glass. We have shown that the CD-1 mouse hepatocytes are adsorbed on the modified and the control glass after 24 h cultivation. Number of these cells on the modified glass was 2.

[Anticancer properties of Trichoderma asperellum 302 from buried soils].

Melanoma is one of the most malignant tumors, which leaves no chance of survival in the case of the "bang". There are various ways to treat tumors, however, recently in the field of cancer research, there are studies in which fungal metabolites have been used as antitumor agents. In this study we examined the effect of the culture fluid of the fungus Trichoderma asperellum 302 on the growth and development of melanoma B 16.

Cytotoxicity of Trichoderma spp. cultural filtrate against human cervical and breast cancer cell lines.

Trichoderma spp. are known as a rich source of secondary metabolites with biological activity belonging to a variety of classes of chemical compounds. These fungi also are well known for their ability to produce a wide range of antibiotic substances and to parasitize other fungi.

Effects of dimephosphone, xydiphone, and ionol on the content and activities of rat liver cytochromes P-450 during long-term treatment with phenobarbital.

Effects of dimephosphone, xydiphone, and ionol administered in parallel with phenobarbital on the content of cytochromes P-450 in rat liver and on the rate of C-hydroxylation of diazepam, haloperidol, and prednisolone by rat liver microsomal enzymes were studied in vitro. Dimephosphone, xydiphone, and ionol exhibited similar inductive effects on C-hydroxylation reactions in the CYP P-450 system during treatment with phenobarbital. Xydiphone and ionol in a dose of 1 mmol/kg canceled phenobarbital-induced increase in P-450 cytochrome content in rat liver.

[An evaluation of the genotoxicity of nonionogenic surface-active substances].

The mutagenic activity of 16 industrial nonionic surfactant samples has been investigated in Ames-test without metabolic activation and with the use of mouse liver microsomal fraction in vitro. The genotoxical estimation of their possible biodegradation products is given. The mutagenicity of a number of high molecular polyethylene glycoles related to nonionic surfactants is shown.

Cytochrome P-450-dependent catabolism of triethanolamine in Rhodotorula mucilaginosa.

The yeast Rhodotorula mucilaginosa was able to grow in media containing triethanolamine or diethanolamine as the sole nitrogen source. During growth in the presence of triethanolamine, extracts of yeast cells contained increased levels of cytochrome P-450 dependent monooxygenase which catalyzed the oxidative N-dealkylation of aminoalcohols. Formation of diethanolamine, ethanolamine and glyoxylate from triethanolamine was demonstrated, and the identity of the products was verified by thin layer chromatography.