Publications by authors named "Fatou Gueye Tall"
Metabolomics is a powerful data-driven tool for in-depth biological phenotyping that could help identify the specific metabolic profile of cryptogenic strokes, for which no precise cause has been identified. We performed a targeted quantitative metabolomics study in West African patients who had recently suffered an ischemic stroke, which was either cryptogenic ( = 40) or had a clearly identified cause ( = 39), compared to a healthy control group ( = 40). Four hundred fifty-six metabolites were accurately measured.
View Article and Find Full Text PDFSickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state.
View Article and Find Full Text PDFObjective: Sickle cell anemia (SCA) can cause substantial kidney dysfunction resulting in sickle cell nephropathy, which may be affected by the presence of modifier genes. This study evaluates the effects of some modifier genes on sickle cell nephropathy.
Methods: Patients living with SCA were recruited.
Article Synopsis
- Oxidative stress is linked to sickle cell anemia (SCA) and is influenced by genetic factors like alpha-thalassemia, which appears to reduce certain oxidative stress indicators in affected children.
- A study of 301 Senegalese SCA children revealed that oxidative stress biomarkers (like CAT and MDA) were significantly different compared to healthy controls, with specific gene variants affecting these levels and clinical severity of the disease.
- Notably, children with earlier complications had different antioxidant enzyme levels, suggesting a complex relationship between genetics, oxidative stress, and SCA severity.
Background: Our objective was to investigate the combined and differential effects of alpha-thalassemia -3.7 kb deletion and HbF-promoting quantitative trait loci (HbF-QTL) in Senegalese hydroxyurea (HU)-free children and young adults with sickle cell anemia (SCA).
Procedure: Steady-state biological parameters and vaso-occlusive crises (VOC) requiring emergency admission were recorded over a 2-year period in 301 children with SCA.
Sickle cell disease is a genetic disorder with a large variability in the pattern and severity of clinical manifestations. Different genetic modulators have been identified but very few epidemiologic data are available on these modifier genes in Senegal. This study aimed to determine their prevalence in a Senegalese sickle cell disease pediatric population.
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