Comprehensive analysis of electrochemical biosensors for early ovarian cancer detection.

Ovarian cancer is one of the leading causes of mortality among women worldwide. However, early detection can significantly reduce mortality rates and mitigate subsequent complications related to both economic burden and mental well-being. Despite the development in the field of medical diagnosis, the death rates due to ovarian cancer have sharply increased.

Doxorubicin-loaded methoxy-intercalated kaolinite as a repackaging of doxorubicin for an enhanced breast cancer treatment: in vitro and in vivo investigation.

Doxorubicin is one of the most common wide-spectrum chemotherapeutics. However, its efficacy is limited due to off-target accumulation and selectivity issues. In this study, we compared the anti-cancer effect and biocompatibility of KaoliniteMeOH-Dox, a doxorubicin repackaging, to doxorubicin monotherapy.

Radiation sensor based on a 1D-periodic structure infiltrated by (B-co-MP) a conjugated copolymer.

In this study, a novel gamma-ray radiation sensor has been developed depending on a 1D photonic crystal (1D-PhC). Based on porous silicon (PSi) layer that has been penetrated by a conjugated copolymer (B-co-MP) which consists of BEHP-PPV and MEH-PPV, with a fractional ratio of 60:40. The suggested method for the development of the dosimeter is based on the shift of photonic band-gap to shorter wavelengths, where exposure to gamma-ray radiation at doses ranging from 0 to 20 kGy alters the refractive index of the (B-co-MP) copolymer.

Bidentate bromhexine drug coordination modes with various transition metal ions: Synthesis, characterization, and in vitro antibacterial and anti-breast cancer activity tests.

Background: Bromhexine (BHX) is a mucolytic drug used in treatment the respiratory disorders which are associated with excessive or viscid mucus. Transition metal complexes have made tremendous progress in the treatment of a variety of human ailments, according to reported articles. Transition metal complexes are being developed as medications with a lot of effort.

Angular surface plasmon resonance-based sensor with a silver nanocomposite layer for effective water pollution detection.

For sensing various samples of polluted water and various sodium chloride concentrations using an angular surface plasmon resonance (ASPR), we have introduced a conventional structure and a hybrid heterostructure in the current research. The suggested structures are composed of silver metal, dielectric layers, silver nanocomposite, and a sensing medium. The reflectance spectra of all structures in the visible region were obtained through the utilization of the transfer matrix method by using the angular interrogation method depending on the Kretschmann configuration.

Sonochemical synthesis of heterostructured ZnO/BiO for photocatalytic desulfurization.

In this study, metal oxides nanoparticles heterogeneous photocatalysts prepared by coprecipitation and ultrasonic techniques were used for diesel desulfurization. They were characterized by scanning electron microscope, powder X-ray diffraction, energy dispersive analysis, diffused reflectance spectra, photoluminescence analysis and BET surface area. The surface area of catalyst B is larger than catalyst A confirming its higher reactivity.

Some novel bioactivities of carotenoids, isolated from Wadi El-Natrun lakes.

Carotenoids come in second among the most frequent natural pigments and are utilized in medications, nutraceuticals, cosmetics, food pigments, and feed supplements. Based on recent complementary work, Virgibacillus was announced for the first time as a member of Wadi El-Natrun salt and soda lakes microbiota, identified as Virgibacillus halodenitrificans, and named V. halodenitrificans DASH; hence, this work aimed to investigate several medicinal bioactivities of V.

Monitoring and simulation of the fuel irradiation behavior in nuclear reactors based on phononic crystal structure.

We have presented in the current work a novel idea for simulating the irradiation behaviors of the nuclear fuel pellets in nuclear reactors by using a one-dimensional defective phononic crystal (1D-DPnC) design was presented. The transmission spectra of the incident mechanical waves were considered basic data for expressing the characteristics of different nuclear fuel-pellets. Herein, the density, sound speed, and Young's modulus of the fuel-pellets represent the key parameters that are influenced by the irradiation behaviors of these pallets.

Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy.

Objective: Cesarean Section (CS) is associated with an increased risk of hemorrhage. Many drugs are used to decrease this risk. We aim to compare the combination of ethamsylate and tranexamic acid, oxytocin, and placebo in women undergoing CS.

A doped-polymer based porous silicon photonic crystal sensor for the detection of gamma-ray radiation.

In this research, a theoretical investigation of the one-dimensional defective photonic crystals is considered for the detection of gamma-ray radiation. Each unit cell of the considered one-dimensional photonic crystals (1D PhCs) is composed of two layers designed from porous silicon infiltrated by poly-vinyl alcohol polymer doped with crystal violet (CV) and carbol fuchsine (CF) dyes (doped-polymer) with different porosity. In addition, a single layer of doped-polymer is included in the middle of the designed 1D PhCs to stimulate the localization of a distinct resonant wavelength through the photonic band gap.

Morphologic design of nanostructures for enhanced antimicrobial activity.

Despite significant progress in synthetic polymer chemistry and in control over tuning the structures and morphologies of nanoparticles, studies on morphologic design of nanomaterials for the purpose of optimizing antimicrobial activity have yielded mixed results. When designing antimicrobial materials, it is important to consider two distinctly different modes and mechanisms of activity-those that involve direct interactions with bacterial cells, and those that promote the entry of nanomaterials into infected host cells to gain access to intracellular pathogens. Antibacterial activity of nanoparticles may involve direct interactions with organisms and/or release of antibacterial cargo, and these activities depend on attractive interactions and contact areas between particles and bacterial or host cell surfaces, local curvature and dynamics of the particles, all of which are functions of nanoparticle shape.

Surface modification of thin film composite forward osmosis membrane using graphene nanosheets for water desalination.

In this study, the main motivation of this work is desalination of water for irrigation arid area such as Sidri- Baba basins- south Sinai, Egypt. Also, the novelty of this work is modification of TFC surface membrane by mix of HA, DA and GO to get high performance of FO technique. Interfacial polymerization was employed to modify a thin-film composite (TFC) membrane for forward osmosis (FO) applications; moreover, graphene oxide (GO) nanosheets (GONs), a dopamine solution (DA), and naturally accessible humic acid (HA) were modified on a polyethersulfone (PES) substrate.

Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based assessment.

Paracetamol is generally recommended for pain and fever. However, as per experimental and epidemiological data, widespread and irrational or long-term use of paracetamol may be harmful to human endocrine homeostasis, especially during pregnancy. Some researchers suggest that prenatal exposure to paracetamol might alter fetal development and also enhance the risk of reproductive disorders.

Design, Structural Inspection and Bio-Medicinal Applications of Some Novel Imine Metal Complexes Based on Acetylferrocene.

Some novel imine metal chelates with Cr, Mn, Fe, Co, Ni, Cu, Zn, and Cd cations were produced from 2-acetylferrocene and 3-aminophenol. The new acetylferrocene azomethine ligand ((Z)-cyclopenta-1,3-dien-1-yl(2-(1-((3-hydroxyphenyl)imino)ethyl)cyclopenta-2,4-dien-1-yl)iron) and its metal ion chelates were constructed and elucidated using FT-IR, UV/Vis, HNMR, DTA/TGA, CHNClM studies, mass spectrometry and SEM analysis. According to the TGA/DTG investigation, the ferrocene moiety spontaneously disintegrates to liberate FeO.

Synthesis, Spectroscopic, Structural and Molecular Docking Studies of Some New Nano-Sized Ferrocene-Based Imine Chelates as Antimicrobial and Anticancer Agents.

The newly synthesized organometallic acetyl ferrocene imine ligand (HL) was obtained by the direct combination of 2-acetyl ferrocene with 2-aminothiophenol. The electronic and molecular structure of acetyl ferrocene imine ligand (HL) was refined theoretically and the chemical quantum factors were computed. Complexes of the acetyl ferrocene imine ligand with metal(II)/(III) ions (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)) were fabricated.

The Photocatalytic Performance of NdO Doped CuO Nanoparticles with Enhanced Methylene Blue Degradation: Synthesis, Characterization and Comparative Study.

The growth of the textile industry results in a massive accumulation of dyes on water. This enormous rise in pigments is the primary source of water pollution, affecting the aquatic lives and our ecosystem balance. This study aims to notify the fabrication of neodymium incorporated copper oxide (NdO doped CuO) nanoparticles by combustion method for effective degradation of dye, methylene blue (MB).

A Novel Electrically Small Ground-Penetrating Radar Patch Antenna with a Parasitic Ring for Respiration Detection.

An electrically small patch antenna with a low-cost high-permittivity ceramic substrate material for use in a ground-penetrating radar is proposed in this work. The antenna is based on a commercial ceramic 915 MHz patch antenna with a size of 25 × 25 × 4 mm and a weight of 12.9 g.

KAP-COVID: a multinational survey of the levels and determinants of public knowledge, attitudes and practices towards COVID-19.

Objective: The adherence to public health recommendations to control COVID-19 spread is influenced by public knowledge, attitudes and practices (KAP). We performed this cross-sectional study to assess the levels and determinants of public KAP towards COVID-19 in a large, multinational sample.

Design: Cross-sectional study (survey).

Cytotoxicity and genotoxicity of gold nanorods assisted photothermal therapy against Ehrlich carcinoma in-vivo.

Aim: Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities.

Materials And Methods: Prepared PEG-AuNRs were characterized by measuring their absorption spectra, zeta potential, and transmission electron microscope (TEM).

Defect mode tunability based on the electro-optical characteristics of the one-dimensional graphene photonic crystals.

New (to the best of our knowledge) photonic crystal optical filters with unique optical characteristics are theoretically introduced in this research. Here, our design is composed of a defect layer inside one-dimensional photonic crystals. The main idea of our study is dependent on the tunability of the permittivity of graphene by means of the electro-optical effect.

Intralesional zinc sulfate 2% vs intralesional vitamin D in plantar warts: A clinicodermoscopic study.

Verrucae are benign proliferations seen in skin due to infection with papillomaviruses. There are different treatment strategies for warts but all of these treatments are painful, time consuming, expensive, and recurrence is common. To evaluate and compare the efficacy of intralesional 2% zinc sulfate solution vs vitamin D3 in the treatment of plantar warts, as well as reporting the side effects.

Efficient photocatalytic removal of safarnin-O dye pollutants from water under sunlight using synthetic bentonite/polyaniline@NiO photocatalyst of enhanced properties.

This study involves a synthesis of bentonite/polyaniline composite (BE/PANI) of enhanced physicochemical properties as catalyst support for NiO photocatalyst. The change in the structural properties, morphological features, and optical behavior was addressed utilizing several analytic techniques. The characterization results reflected considerable enhancement in the specific surface area after the integration between bentonite and polyaniline (127 m/g) and after loading of the campsite by NiO forming bentonite/polyaniline@NiO composite (BE/PANI@NiO) (231 m/g).

Virulence of geographically different Cryptosporidium parvum isolates in experimental animal model.

Cryptosporidium parvum is a coccidian parasite which causes gastrointestinal disease in humans and a variety of other mammalian species. Several studies have reported different degrees of pathogenicity and virulence among Cryptosporidium species and isolates of the same species as well as evidence of variation in host susceptibility to infection. The study aimed to investigate infectivity and virulence of two Cryptosporidium parvum “Iowa isolate” (CpI) and a “local water isolate” (CpW).

SODIUM DODECYL SULPHATE POLYACRILAMIDE GEL ELECTROPHORESIS (SDS-PAGE) FOR DIFFERENTIATION OF DIFFERENT SCHISTOSOME AND FASCIOLID SPECIES.

Fasciola and Schistosoma spp. are digenetic trematodes that have a major detrimental impact on human health worldwide. It is not unusual to find common molecules among parasites of different species, genera, or phyla.