Publications by authors named "Fatma Marghany"
Article Synopsis
- Active ingredients in pesticides and chemicals can harm ecosystems, prompting European laws for chemical risk assessments and banning endocrine disruptors, substances that affect hormone systems.
- Traditional methods to identify thyroid hormone disruptors are expensive and require large numbers of amphibians, highlighting the need for alternative methods that adhere to the 3R principle (replacement, reduction, refinement).
- Our study identified specific biomarker genes in zebrafish embryos exposed to thyroid disruptors, indicating potential for more accurate risk assessments and development of safer chemicals in the future.
In this study, we applied OMICs analysis to identify substance-specific biomarker candidates, which may act as early indicators for specific ecotoxic modes of actions (MoA). Zebrafish embryos were exposed to two sublethal concentrations of difenoconazole and metalaxyl according to a modified protocol of the OECD test guideline No. 236.
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