Publications by authors named "Fatma Magdoud"
We previously identified an operon involved in an arginine deiminase (ADI) pathway ( operon) on a CTX-M-producing plasmid from an O102-ST405 strain of As the ADI pathway was shown to be involved in the virulence of various Gram-positive bacteria, we tested whether the ADI pathway could be involved in the epidemiological success of extended-spectrum-β-lactamase (ESBL)-producing strains. We studied two collections of human isolated in France ( = 493) and England ( = 1,509) and show that the prevalence of the operon (i) is higher in ESBL-producing strains (12.1%) than in nonproducers (2.
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- Hypervirulent Klebsiella pneumoniae (hvKp) is increasingly responsible for severe pneumonia and other infections in the East, but data is limited in the West.* -
- A 5-year study in a French ICU found 12 hvKp infections out of 59 K. pneumoniae cases, with notable occurrences like community-acquired pneumonia and liver abscesses.* -
- Patients with hvKp had higher multi-organ failure rates compared to non-hvKp infections, indicating its severity, although mortality rates were similar.*
The epidemiology of multidrug-resistant bacteria (MDRB) has changed significantly in European healthcare settings, with a decrease in frequency of meticillin-resistant Staphylococcus aureus and an increase in extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Little is known about the effects of these changes on ventilator-associated pneumonia (VAP). A retrospective 5-year trend analysis of ICU antibiotic consumption and resistance in bacteria causing VAP was undertaken.
View Article and Find Full Text PDFPurpose: To characterize Escherichia coli ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients by determining antibioresistance and genotypic characteristics of E. coli isolates responsible for VAP or lung colonization, by comparing them with their oropharyngeal and rectal counterparts and by assessing representative isolates' virulence in a pneumonia mouse model.
Methods: Patients under mechanical ventilation for more than 72 h were screened for simultaneous presence of E.