Publications by authors named "Fatma H El Nouby"
T helper 17 (Th17) cells have been reported to be the most powerful factor in autoimmune disorder pathogenesis, which points to the Th17 master cytokine, interleukin (IL)-17A, as the crucial mediator. We aimed to determine the impact of IL-17A polymorphism in the -197 G/A promoter region on level of IL-17 and intensity of rheumatoid arthritis (RA) disease symptoms. This case-control study was conducted at the Department of Clinical Rheumatology of Aswan university Hospital and included 35 people suffering RA and 30 volunteer controls, matched for age and sex.
View Article and Find Full Text PDFBackground And Objectives: The highest incidence of death in systemic sclerosis due to pulmonary disease raises the need for early detection and treatment. The study aim is the assessment of interstitial pulmonary disease by Multi Detector High Resolution CT (MDCT) and finds its relationship with the other disease parameters and the Pulmonary Function tests (PFT).
Patients And Methods: A prospective cross-sectional study was performed in Assiut University Hospitals from May 2018 to January 2020 and included 62 consecutive SSc female patients.
Background And Objectives: The highest incidence of death in systemic sclerosis due to pulmonary disease raises the need for early detection and treatment. The study aim is the assessment of interstitial pulmonary disease by Multi Detector High Resolution CT (MDCT) and finds its relationship with the other disease parameters and the Pulmonary Function tests (PFT).
Patients And Methods: A prospective cross-sectional study was performed in Assiut University Hospitals from May 2018 to January 2020 and included 62 consecutive SSc female patients.
Article Synopsis
- Rheumatoid arthritis (RA) is a common autoimmune disorder influenced by genetic factors, particularly involving the VDR gene polymorphisms BsmI and FokI, which may impact immune system functioning.
- A study assessed the correlation between these gene polymorphisms and various inflammatory biomarkers in 131 individuals, including 70 RA patients and 61 healthy controls, finding that RA patients had significantly higher levels of these biomarkers.
- The research revealed that specific genotypes of the BsmI and FokI polymorphisms were linked to greater RA activity, suggesting that vitamin D's immunoregulatory properties might play a role in the inflammatory processes associated with RA.
Objective: This is a secondary analysis of a randomized controlled trial that aimed to assess subclinical atherosclerosis in patients with rheumatoid arthritis (RA) by measuring carotid artery intima-media thickness (CIMT) and correlating it with disease activity and inflammatory markers (including levels of matrix metalloproteinase-3(MMP-3) and matrix metalloproteinase-9 (MMP-9)) and to detect the effectiveness of agents that inhibit matrix metalloproteinases (MMPs) as doxycycline in RA therapy.
Methods: One hundred and sixty RA patients were assigned in a randomized clinical trial (clinicaltrial. gov NCT03194204).