Synthesis and Biological Evaluation of Benzothiazolyl-pyridine Hybrids as New Antiviral Agents against H5N1 Bird Flu and SARS-COV-2 Viruses.

A novel series of benzothiazolyl-pyridine hybrids - and - were produced from the reaction of enamine derivative with each of the arylcyanoacetamides - and cyanoacetohydrazides -. The new products were characterized by spectral techniques (IR, H NMR, C NMR, and MS). Biological evaluation of - and - in against H5N1 and SARS-COV-2 viruses showed that several compounds had significant activity.