Publications by authors named "Fatma G Metwally"
There are good evidences suggesting that endoplasmic reticulum (ER) stress can be one of the contributing factors in the development of diabetic retinopathy. The present study was designed to investigate the effect of chemical chaperone 4-phenylbutyric acid (4-PBA) in alleviating the ER stress, and diabetic retinopathy in type 2 diabetic rats. Treatment of diabetic rats with 4-PBA, increased the antioxidant capacity, reduced the levels of lipid peroxidation, organised the state of apoptosis and regulated the ER stress - oxidative activation in retinal tissue.
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- Tramadol, a widely used opioid analgesic, can cause oxidative stress and significant testicular damage in both adult and adolescent rats, as demonstrated by various structural changes and increased collagen levels.
- Pomegranate seed extract (PgSE) was found to provide protective effects against these tramadol-induced damages, preventing many of the observed abnormalities in testicular structure and function.
- The study suggests that the high levels of polyphenols and flavonoids in PgSE, along with its strong antioxidant activity, contribute to its ability to safeguard against the adverse effects of tramadol, especially in younger rats.