Affecting Factors Unfavorable Treatment Outcomes of Rifampicin-resistant/Multidrug-resistant Tuberculosis Patients Treated with Long-term Regimen.

Background: Drug-resistant tuberculosis (DR-TB) poses a significant threat to global TB control and remains a major public health issue. This study aims to evaluate treatment outcomes and identify risk factors for unfavorable outcomes in patients with multi-DR-TB (MDR-TB) treated at a major reference hospital in Istanbul.

Methods: We conducted a retrospective analysis of 413 patients with rifampicin-resistant and MDR-TB who received treatment between January 1, 2013, and December 31, 2023, at the University of Health Sciences Süreyyapaşa Chest Diseases Training and Research Hospital.

Two Difficult Pandemics: Tuberculosis and COVID-19.

Background: The coinfection of Mycobacterium tuberculosis and SARS-CoV-2 is called tuberculosis and COVID-19 coinfection (TB-COVID-19). We aimed to share the clinical, radiological, and laboratory findings and treatment processes of our patients with TB-COVID-19 coinfection in our tertiary reference hospital.

Methods: Patients aged 18 years and over and hospitalized in the tuberculosis service between March 2020 and September 2022 were included.

Evaluation of the Patients with the Diagnosis of Pontocerebellar Hypoplasia: A Multicenter National Study.

Pontocerebellar hypoplasia (PCH) is a heterogeneous group of neurodegenerative disorders characterized by hypoplasia and degeneration of the cerebellum and pons. We aimed to identify the clinical, laboratory, and imaging findings of the patients with diagnosed PCH with confirmed genetic analysis. We collected available clinical data, laboratory, and imaging findings in our retrospective multicenter national study of 64 patients with PCH in Turkey.

Determination of micronuclei frequency in for assessing genotoxicity induced by propineb.

The aim of this study was to investigate the genotoxic effect of Propineb fungicide at different concentrations (0.167, 0.335 and 0.

The impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study.

Background: Factors such as age, underlying hematological disease, chemotherapy and radiotherapy used, and bone marrow infiltration may cause mobilization failure. Several preclinical observed that diabetes mellitus (DM) leads to profound remodeling of the hematopoietic stem cell (HSC) niche, resulting in the impaired release of HSCs. We aim to examine the effect of DM on HSC mobilization and to investigate whether there is a relationship between complications developing in the DM process and drugs used to treat DM and mobilization failure.

Rationale, design and methodology of APPROACH-IS II: International study of patient-reported outcomes and frailty phenotyping in adults with congenital heart disease.

Background: In recent years, patient-reported outcomes (PROs) have received increasing prominence in cardiovascular research and clinical care. An understanding of the variability and global experience of PROs in adults with congenital heart disease (CHD), however, is still lacking. Moreover, information on epidemiological characteristics and the frailty phenotype of older adults with CHD is minimal.

Drosophila as a Suitable In Vivo Model in the Safety Assessment of Nanomaterials.

Nanotechnology is often praised as the future technology that will revolutionize the world as we know it, because nanomaterials (NMs) offer numerous practical applications for a wide range of fields such as medicine, cosmetics, food preservation, paintings, and industry. Produced by nanotechnology, NMs are in the front line of this innovative applied science, while nanoparticles (NPs) refer to materials existing in the natural world and measuring 1-100 nanometers in at least one dimension. The recent surge in the number of endeavors to utilize NMs makes it imperative to identify hazards and risk factors involved as we have yet to know harmful effects of this uncharted territory on the environment and public health.

Characterization of cord blood CD3 TCRVα7.2 CD161 T and innate lymphoid cells in the pregnancies with gestational diabetes, morbidly adherent placenta, and pregnancy hypertension diseases.

Problem: Although pregnant women with gestational diabetes (GD), morbidly adherent placenta (MAP), and pregnancy hypertension (pHT) diseases lead to intrauterine growth restriction (IUGR), little is known about their effect on mucosal-associated invariant T (MAIT) and innate lymphoid cells (ILC) in the umbilical cord. This study aimed to quantify and characterize MAIT cells and ILCs in the cord blood of pregnant women with GD, MAP, and pHT diseases.

Method Of Study: Cord blood mononuclear cells (CBMCs) were isolated by Ficoll-Paque gradient.

Formation and characterization of mechanochemically generated free lignin radicals from olive seeds.

In this study, formation and quantification of mechanochemically generated free radicals of lignin were evaluated after the extraction of lignin from olive seeds and detailed lignin characterization was performed. Lignin was extracted from crushed olive seeds as an insoluble solid using Klason method. Isolated lignin was mechanochemically grinded under cryo conditions using Cryomill and particlesizes were determined by using Zeta Sizer, structural changes were followed by XRD and FTIR-ATR; thermal stabilities were tracked by TGA and DSC.

Ganglion Impar block improves neuropathic pain in coccygodynia: A preliminary report.

Aim Of The Study: To define the effectiveness of ganglion Impar block in improving neuropathic pain.

Materials And Methods: Patients who had pain around the coccyx for more than three months and did not respond to conservative treatment were included in this study. All the patients underwent fluoroscopy guided transsacrococcygeal ganglion Impar block with injecting 3 mL of 0.

Emission tunable, cyto/hemocompatible, near-IR-emitting Ag2S quantum dots by aqueous decomposition of DMSA.

Size tunable aqueous Ag2S quantum dots emitting in the near-infrared region were synthesized through decomposition of meso-2,3-dimercaptosuccinic acid (DMSA) in water. The resulting NIR QDs are highly cyto- and hemocompatible, have quantum yields as high as 6.5% and are effective optical imaging agents based on in vitro evaluation.

A survey on prevention of surgical infections in operating theaters.

Background: It is well known that surgical site infections (SSIs) contribute significantly to the cost of nosocomial infections. Although many guidelines and recommendations exist, research has demonstrated that practices for preventing SSIs in operating theaters (OT) vary.

Aim: The purpose of this study was to describe the current infection control practices for SSIs, formerly called surgical wound infections, in OTs, and compare these findings with evidence-based practice guidelines.

Presence of patients' families during cardiopulmonary resuscitation: physicians' and nurses' opinions.

Aim: This paper is a report of a study to determine the opinions of physicians and nurses who work in a university hospital intensive care unit and emergency department about the presence of patients' families during cardiopulmonary resuscitation in these units.

Background: Healthcare professionals have conflicting opinions about the presence of patients' families during cardiopulmonary resuscitation. Families who are allowed to be present have less fear and worry, feel they have supported their family member and are able to cope more easily.

Patients' lived experiences of excisional breast biopsy: a phenomenological study.

Aims: The purpose of this study was to explore the lived experience of patients undergoing an excisional breast biopsy.

Background: It has been determined that women who feel a lump or a lesion in their breast delay seeking medical treatment because it could be cancer and they might need a mastectomy and/or the cancer may not be treatable. After women go to a health-care facility and are told that they need to have a biopsy to make a clear diagnosis they want to have the biopsy performed as soon as possible.

The quality and suitability of written educational materials for patients*.

Aim: In this study, the quality and suitability of written educational materials being used for the education of patients in surgical departments of hospitals were studied.

Background: In the literature, it is stated that most of the educational materials for patients are not suitable from the aspects of contents, structure, design, composition and language.

Method: In this descriptive type study, which was carried out between March and May 2006, 59 examples of written educational material used for patient education at 138 surgical clinics were evaluated for quality and suitability.

Requirement for 100% oxygen before and after closed suction.

Aim: This paper reports an experimental study to determine whether giving 100% oxygen for 1 minute before and after closed suctioning is required.

Background: Some studies suggest that patients receiving closed suction do not require preoxygenation to minimize desaturation.

Methods: The study was conducted in 2002, with 30 patients receiving mechanical ventilation who had various positive end-expiratory levels.