Publications by authors named "Fatma Amari"
Identifying biomarkers able to discriminate individuals on different health trajectories is crucial to understand the molecular basis of age-related morbidity. We investigated multi-omics signatures of general health and organ-specific morbidity, as well as their interconnectivity. We examined cross-sectional metabolome and proteome data from 3,142 adults of the Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed to investigate how human biology, environment, and lifestyle factors contribute to people's health over time.
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- - Accessing the genetic diversity of species uncovers hidden traits and helps clarify gene functions, especially in natural isolates of Saccharomyces cerevisiae, where around 20% exhibit aneuploidy, which is contradicted by laboratory findings showing its fitness costs.
- - The research generates a proteomic resource for 796 euploid and aneuploid isolates, revealing that natural aneuploids have better protein dosage compensation compared to lab-generated ones, where many protein subunits show reduced expression.
- - Findings indicate that natural aneuploidy involves enhanced protein turnover and structural changes in the proteasome, suggesting that studying natural genetic diversity can provide valuable insights into the biological mechanisms behind aneupl
Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. However, our knowledge regarding the species-wide genetic control of protein abundance, including its dependency on transcript levels, is very limited. Here, we have determined quantitative proteomes of a large population of 942 diverse natural yeast isolates.
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