Publications by authors named "Fatma Alibaz Oner"
Article Synopsis
- The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
- A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
- Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
Objective: To evaluate the cardiac involvement in patients with Still's disease with a focus on myocarditis included in the multicenter AIDA (AutoInflammatory Disease Alliance) network Still's disease registry. To exploit the predictive factors for myocarditis in deriving a clinical risk patient profile for this severe manifestation.
Methods: A multicenter observational study was built up assessing consecutive patients with Still's disease characterized by the cardiac involvement among those included in the AIDA Network Still's Disease Registry.
Clinical course of pediatric-onset Behçet's Disease in young adulthood.
Rheumatology (Oxford)
November 2024
Article Synopsis
- The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
- Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
- The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
Objectives: Pulmonary arterial involvement (PAI) is one of the most common causes of mortality in Behçet's disease (BD). In this study, we aimed to evaluate the clinical features, course, and recurrence risk factors of BD-associated PAI.
Methods: BD patients who were followed up in Marmara University BD outpatient clinic between 1990 and 2023 were included.
Article Synopsis
- Behçet disease (BD) presents with various symptoms, including mucocutaneous, ocular, and vascular manifestations, and this study explores the immune-related cytokines involved in these different BD types.
- Researchers analyzed serum samples from active and remission stages of BD patients, comparing them with healthy controls, to evaluate the levels of specific cytokines like interferon γ and interleukin 35.
- The findings indicate distinct immune responses for each BD phenotype, particularly showing that the IL-17 response is less pronounced in ocular BD, suggesting a need for targeted treatments based on cytokine patterns in various BD subtypes.
Objectives: We aimed to assess first degree relatives (FDRs) of BD patients for the presence of clinical symptoms and signs of BD and evaluate common femoral vein (CFV) wall thickness measurement for the diagnosis.
Methods: Patients with BD(n=129) and FDRs(n=230) of these patients were included. FDRs were questioned in terms of BD symptoms by phone.
Post-thrombotic syndrome (PTS) is a frequent and important consequence of deep vein thrombosis (DVT) for Behcet`s disease (BD) patients. Although various clinical scales are used to diagnose PTS, Villalta scale was accepted as the standard tool to diagnose and grade the severity of PTS. Poor quality of life (Qol) in the general population was defined for patients with PTS, however, studies in BD patients with PTS is limited.
View Article and Find Full Text PDFPurpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet's disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.
Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.
Article Synopsis
- The study investigates the effectiveness of two common immunosuppressive agents, methotrexate (MTX) and azathioprine (AZA), as first-line treatments for patients with Takayasu's arteritis (TAK), analyzing patient outcomes and safety.
- A total of 301 TAK patients from 10 centers were included; findings revealed similar remission and relapse rates between MTX and AZA, but a significantly higher rate of vascular surgery in the AZA group compared to MTX.
- The study also noted that patients on MTX were more likely to receive lower doses of glucocorticoids post-treatment compared to those on AZA, indicating different management outcomes between the
Article Synopsis
- - The study investigated the occurrence of spondyloarthritis (SpA) features in 350 patients with Takayasu arteritis (TAK), finding that 8.8% had additional SpA-related conditions, such as inflammatory bowel disease (IBD) or psoriasis.
- - Patients with both TAK and SpA displayed earlier onset of disease symptoms and required more aggressive biological treatments for active vasculitis compared to those with TAK alone.
- - The research highlighted the overlap between TAK and SpA, suggesting a potential link in their pathogenesis, possibly related to an MHC class I allele similar to that seen in spondyloarthritis.
Article Synopsis
- A study examined cancer rates in patients with ANCA-associated vasculitis (AAV) by comparing them to cancer risks in the Turkish population and identifying independent risk factors.
- Of the 461 AAV patients tracked, 19 developed cancer after an average follow-up of about 3.4 years, with higher cancer risks noted in older males and those with anti-PR3-ANCA positivity.
- The overall cancer risk for AAV patients was 2.1 times higher than that of the general population, highlighting the need for targeted cancer screening, especially for lung and head-neck cancers in older male patients.
Article Synopsis
- This study evaluated the effectiveness of a systemic score in predicting severe outcomes in patients with Still disease, including the risk of mortality and severe complications like macrophage activation syndrome.
- Involving 597 patients, the study found that a higher systemic score significantly correlated with life-threatening outcomes, with scores of 7 or above indicating a greater risk.
- Key components that were most predictive of severe outcomes included liver and lung involvement, emphasizing the importance of these factors in managing Still disease.
Article Synopsis
- The study investigates the wall thickness of the inferior vena cava (IVC) in patients with Behçet's disease (BD) compared to healthy controls, revealing that BD patients have significantly thicker IVC walls.
- Results showed that IVC wall thickness is associated with mucocutaneous and major organ involvement, indicating a correlation between vascular issues and BD symptoms.
- The findings suggest that venous wall inflammation in BD affects not only lower extremity veins but also larger venous structures like the IVC, pointing to a widespread vascular inflammation in this disease.
Article Synopsis
- A recent study investigated the thickness of the common femoral vein (CFV) in patients with Behçet's Disease (BD) using Doppler ultrasonography in both standing and supine positions.
- The study involved 42 BD patients and 41 healthy controls, finding that CFV thickness was significantly greater in BD patients compared to healthy individuals.
- The research concluded that Doppler US is a reliable, non-invasive method for diagnosing BD and that the patient's position does not influence the CFV wall thickness measurements.
Article Synopsis
- The study gathered data on 358 patients with polyarteritis nodosa (PAN) from nine countries, analyzing demographics, clinical features, and survival rates over 30 years.
- Findings showed common symptoms such as constitutional issues, skin lesions, joint pain, and neurological problems, with a significant relapse rate of 48.5% during an average follow-up of nearly five years.
- Survival rates for systemic PAN showed a decline over time, with important risk factors for mortality including older age, high serum creatinine levels, and involvement of the gastrointestinal system or central nervous system.
Correction: Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry.
Intern Emerg Med
January 2024
Introduction: The effectiveness of canakinumab may change according to the different times it is used after Still's disease onset. This study aimed to investigate whether canakinumab (CAN) shows differences in short- and long-term therapeutic outcomes, according to its use as different lines of biologic treatment.
Methods: Patients included in this study were retrospectively enrolled from the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Still's disease.
Development of the Takayasu Arteritis Integrated Disease Activity Index.
Arthritis Care Res (Hoboken)
April 2024
Objective: Accurate clinical assessment of disease activity in Takayasu arteritis (TAK) can be challenging. F-fluorodeoxyglucose-positron emission tomography (FDG-PET) can directly measure vascular inflammation. This study details the development of a new type of disease activity index called the Takayasu's Arteritis Integrated Disease Activity Index (TAIDAI).
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates whether pediatric-onset, adult-onset, and elderly-onset Still's disease are the same condition or different diseases by comparing demographic, clinical, and treatment response data across these age groups.
- - Out of 411 patients surveyed, most were adults (76.4%), while 15.8% were pediatric and 7.8% were elderly, with significant differences found in symptoms like skin rash and arthritis being more prevalent in children, and pleuritis in the elderly.
- - Overall, while some minor differences in symptoms and lab results were noted among the age groups, the study concludes that Still's disease has similar demographic and treatment characteristics across pediatric, adult, and elderly patients.
Introduction: Behcet's disease (BD) is a chronic inflammatory disorder with arterial vasculitis. Although, pulmonary artery aneurysm (PAA) is accepted as the prototypic arterial disorder, an increasing presence of pulmonary artery thrombosis (PAT) with or without aneurysms was also reported in recent studies. In this study, we aimed to describe computed tomography pulmonary angiography (CTPA) findings of pulmonary involvement and its correlation with symptoms and acute phase response in BD.
View Article and Find Full Text PDFBackground: Different patient clusters were preliminarily suggested to dissect the clinical heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters in a multicentre, observational, prospective study to stratify these patients.
Methods: Patients included in GIRRCS AOSD-study group and AIDA Network Still Disease Registry were assessed if variables for cluster analysis were available (age, systemic score, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and ferritin).
Article Synopsis
- * Researchers analyzed data from 330 patients diagnosed with GCA, finding that 18.8% experienced relapses during a follow-up period, and only 23.8% were able to stop GC treatment entirely.
- * The study highlighted that a significant portion of patients (66.2%) had at least one indication of damage due to vasculitis, and there were also considerable side effects related to GC treatment.
Article Synopsis
- The study used the CART algorithm to analyze treatment protocols and factors affecting oral ulcers in Behçet's syndrome patients across multiple countries.
- Among 979 patients, findings revealed that those with irregular tooth brushing habits showed a higher usage of immunosuppressive (IS) medications, especially in males with major organ involvement.
- The study emphasizes the importance of promoting better oral hygiene as part of treatment strategies for patients with Behçet's syndrome.