Internal parasites (nematode) infestation in pure Arabian horses: Field study.

Background: Hematological and biochemical values are widely used in veterinary clinics for disease prognosis, nutritional and therapeutic monitoring, as well as in understanding the disease process in farm animals, including equines.

Aim: This study aims to assess the alterations in hematological and biochemical parameters in pure Arabian horses infested with internal parasites.

Methods: Samples of feces and blood were collected from 20 adult mares.

Cardioprotective effect of fingolimod against calcium paradox-induced myocardial injury in the isolated rat heart.

Fingolimod (FTY720) inhibits Ca-permeable, Mg-sensitive channels called transient receptor potential melastatin 7 (TRPM7), but its effects on Ca paradox (CP) - induced myocardial damage has not been evaluated. We studied the effect of FTY720 on CP-induced myocardial damage and used other TRPM7 channel inhibitors nordihydroguaiaretic acid (NDGA) and Mg to test if any effect of FTY720 was via TRPM7 inhibition. Langendorff-perfused Wistar rat hearts were treated with FTY720 or NDGA and subjected to a CP protocol consisting of Ca depletion followed by Ca repletion.