Publications by authors named "Fatma Ahmed Aly"
A new analytical quality by design-assisted HPLC-UV approach is presented, for the first time, for the concurrent determination of cetirizine (CTZ) and azelastine (AZE) in raw materials, commercial eye drops and aqueous humor. The two drugs are co-administered as eye drops in severe ocular allergies. A 2 full factorial design was adopted for the chromatographic optimization to ensure the best analytical performance and reliability, as well as to save time, effort and solvent consumption.
View Article and Find Full Text PDFA green, simple and sensitive HPLC method coupled with fluorescence detection was implemented for the quantitative determination of the anti-glaucoma drug tafluprost (TFL). Liquid chromatography was performed on HyperClone™ ODS (C18) column of dimensions; 150 × 4.6 mm i.
View Article and Find Full Text PDFA new, simple and selective HPLC method was implemented for the simultaneous estimation of tafluprost (TFL) and timolol (TIM) in their new anti-glaucoma combination in the challengeable ratio of 3 and 1000 for TFL and TIM, respectively. Separation was achieved using a BDS Hypersil phenyl column and a mobile phase made up of acetonitrile: 0.015 M phosphate buffer (50:50 v/v, pH 3.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the formulation of a tablet named Nemeriv Cp, which combines cetirizine (CET), phenylpropanolamine (PPA), and nimesulide (NMS) to treat nasal congestion, allergies, and associated symptoms, noting a lack of methods for their simultaneous analysis.
- It presents two new methods for quantifying these three drugs: a spectrophotometric method that measures specific wavelengths and an HPLC method using a monolithic column with a defined mobile phase for separation.
- The proposed methods were successfully applied to laboratory-prepared tablets and showed satisfactory comparison with existing methods, indicating their reliability for drug analysis.
A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of gemifloxacin mesylate (GFX) in tablets. The method is based on measuring the native fluorescence of GFX in isopropanol at 400 nm after excitation at 272 nm. The fluorescence-concentration plot was rectilinear over the range of 0.
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