Investigating the Antibacterial Effects of Synthetic Gamma-Lactam Heterocycles on Methicillin-Resistant Strains and Assessing the Safety and Effectiveness of Lead Compound MFM514.

Methicillin-resistant (MRSA) continues to be one of the main causes of hospital-acquired infections in all regions of the world, while linezolid is one of the only commercially available oral antibiotics available against this dangerous gram-positive pathogen. In this study, the antibacterial activity from 32 analogues of synthetic gamma-lactam heterocycles against MRSA was determined. Amongst screened analogues for the minimum inhibitory concentration (MIC) assay, compound displayed good inhibitory activity with MIC values of 7.

-Ethyl -(2,3,4)-4-hy-droxy-1,2-dimethyl-5-oxopyrrolidine-3-carboxyl-ate.

The asymmetric unit of the title compound, CHNO, consists of a functionalized pyrrolidine ring having an envelope conformation, synthesized as an ethyl ester. The mol-ecule has three chiral centres and crystallized as a racemic mixture. In the crystal, mol-ecules are linked by pairwise O-H⋯O bonds, generating dimers with twofold rotational symmetry.