Classification and characteristics of periorbital hyperpigmentation.

Introduction: Periorbital hyperpigmentation (POH) is among the commonest esthetic and dermatological complaints. Despite its frequency, there are inadequate information detailing its incidence and prevalence. This subsequently leads to lack of comprehensive POH classification and stratification of impact on an individual's general well'being.

Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-FeO nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug.

Camptothecin (CPT) is an anti-cancer drug that effectively treats various cancers, including colon cancer. However, poor solubility and other drawbacks have restricted its chemotherapeutic potential. To overcome these restrictions, CPT was encapsulated in CEF (cyclodextrin-EDTA-FEO), a composite nanoparticle of magnetic iron oxide (FeO), and β-cyclodextrin was cross-linked with ethylenediaminetetraacetic acid (EDTA).

Impact of dengue virus (serotype DENV-2) infection on liver of BALB/c mice: A histopathological analysis.

In this research, we characterized the histopathological impact of dengue virus (serotype DENV-2) infection in livers of BALB/c mice. The mice were infected with different doses of DENV-2 via intraperitoneal injection and liver tissues were processed for histological analyses and variation was documented. In the BALB/c mouse model, typical liver tissues showed regular hepatocyte architecture, with normal endothelial cells surrounding sinusoid capillary.