Expression of CD44 is associated with aggressiveness in seminomas.

Background: Testicular germ cell tumors (TGCTs) exhibit diverse biological and pathological features and are divided in two main types, seminomas and nonseminomatous germ cell tumors (NSGCTs). CD44 is a cell surface receptor, which is highly expressed in malignancies and is implicated in tumorigenesis affecting cell-matrix interactions and cell signaling.

Methods And Results: Here, we examined the expression of CD44 in tumor cell lines and in patients' material.

The Expression of Serglycin Is Required for Active Transforming Growth Factor β Receptor I Tumorigenic Signaling in Glioblastoma Cells and Paracrine Activation of Stromal Fibroblasts via CXCR-2.

Serglycin (SRGN) is a pro-tumorigenic proteoglycan expressed and secreted by various aggressive tumors including glioblastoma (GBM). In our study, we investigated the interplay and biological outcomes of SRGN with TGFβRI, CXCR-2 and inflammatory mediators in GBM cells and fibroblasts. SRGN overexpression is associated with poor survival in GBM patients.

Design, Synthesis, Computational Investigations, and Antitumor Evaluation of -Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells.

Nitrogen and sulfur glycosylation was carried out via the reaction of rhodanine () with α-acetobromoglucose under basic conditions. Deacetylation of the protected nitrogen nucleoside was performed with CHONa in CHOH without cleavage of the rhodanine ring to afford the deprotected nitrogen nucleoside . Further, deacetylation of the protected sulfur nucleoside was performed with CHONa in CHOH with the cleavage of the rhodanine ring to give the hydrolysis product .

Investigate the suitability of g-CN nanosheets ornamented with BiOI nanoflowers for photocatalytic dye degradation and PEC water splitting.

The two-step thermal polymerization and solvothermal approach is used to construct nano heterostructures of FCN and BiOI (bismuth oxeye iodide), both of which are Nobel metal-free materials. This work reports the effect nano-heterostructure on the micro-structural, light absorption capability, PEC properties and pollutant degradation efficiency of the synthesised heterostructures. The addition to that formation of FCN/BiOI nano-heterostructure enhances the solar light absorption.

Design, synthesis, molecular modelling and antitumor evaluation of -glucosylated rhodanines through topo II inhibition and DNA intercalation.

In the present study, 5-arylidene rhodanine derivatives , -glucosylation rhodanine , -glucosylation rhodanine , -glucoside rhodanine and -glucosylation 5-arylidene rhodanines were synthesised and screened for cytotoxicity against a panel of cancer cells with investigating the effective molecular target and mechanistic cell death. The anomers were separated by flash column chromatography and their configurations were assigned by NMR spectroscopy. The stable structures of the compounds under study were modelled on a molecular level, and DFT calculations were carried out at the B3LYP/6-31 + G (d,p) level to examine their electronic and geometric features.

Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives.

The unique biological and physicochemical characteristics of biogenic (green-synthesized) nanomaterials (NMs) have attracted significant interest in different fields, with applications in the agrochemical, food, medication delivery, cosmetics, cellular imaging, and biomedical industries. To synthesize biogenic nanomaterials, green synthesis techniques use microorganisms, plant extracts, or proteins as bio-capping and bio-reducing agents and their role as bio-nanofactories for material synthesis at the nanoscale size. Green chemistry is environmentally benign, biocompatible, nontoxic, and economically effective.

In Situ Nitrogen Functionalization of 2D-TiCT-MXenes for High-Performance Zn-Ion Supercapacitor.

Zinc (Zn) ion supercapacitors (ZISCs) have attracted considerable attention as a viable energy storage technology because they are cost-effective, safe, and environmentally friendly. However, cathode materials with suitable properties are rare and need to be explored. In this regard, metal carbides (MXenes) are a good choice for capacitive energy storage, but they exhibit low capacitance.

Synthesis, Characterization and Application of Polypyrrole Functionalized Nanocellulose for the Removal of Cr(VI) from Aqueous Solution.

Heavy metals are toxic substances that pose a real danger to humans and organisms, even at low concentration. Therefore, there is an urgent need to remove heavy metals. Herein, the nanocellulose (NC) was synthesized by the hydrolysis of cellulose using sulfuric acid, and then functionalized using polypyrrole (ppy) through a polymerization reaction to produce polypyrrole/nanocellulose (ppy/NC) nanocomposite.

Magnetic Nitrogen-Doped Porous Carbon Nanocomposite for Pb(II) Adsorption from Aqueous Solution.

We report in the present study the in situ formation of magnetic nanoparticles (FeO or Fe) within porous N-doped carbon (FeO/N@C) via simple impregnation, polymerization, and calcination sequentially. The synthesized nanocomposite structural properties were investigated using different techniques showing its good construction. The formed nanocomposite showed a saturation magnetization (M) of 23.

Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin.

Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate's related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS.

Synthesis of Polymer-Based Magnetic Nanocomposite for Multi-Pollutants Removal from Water.

A magnetic polymer-based nanocomposite was fabricated by the modification of an FeO/SiO magnetic composite with polypyrrole (PPy) via co-precipitation polymerization to form PPy/FeO/SiO for the removal of Congo red dye (CR) and hexavalent chromium Cr(VI) ions from water. The nanocomposite was characterized using various techniques including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), vibration sample magnetometer, and thermogravimetric analysis (TGA). The results confirm the successful fabrication of the nanocomposite in the size of nanometers.

The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review.

Antibiotics can accumulate through food metabolism in the human body which may have a significant effect on human safety and health. It is therefore highly beneficial to establish easy and sensitive approaches for rapid assessment of antibiotic amounts. In the development of next-generation biosensors, nanomaterials (NMs) with outstanding thermal, mechanical, optical, and electrical properties have been identified as one of the most hopeful materials for opening new gates.

Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells.

Background: Yttria-stabilized zirconia (YOZrO) nanoparticles are one of the important nanoparticles extensively used in manufacturing of plastics, textiles, catalyst, etc. Still, the cytotoxic and apoptotic effects of yttria-stabilized zirconia nanoparticles have not been well identified on human skin keratinocyte (HaCaT) cells. Therefore, in this study, we have designed to examine the cytotoxic potential of yttria-stabilized zirconia nanoparticles in HaCaT cells.