Publications by authors named "Fatimah J Al Khazal"

Heterozygosity for loss-of-function alleles of the genes encoding the four subunits of succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly factor predispose affected individuals to pheochromocytoma and paraganglioma (PPGL), two rare neuroendocrine tumors that arise from neural crest-derived paraganglia. Tumorigenesis results from loss of the remaining functional SDHx gene copy, leading to a cell with no functional SDH and a defective tricarboxylic acid (TCA) cycle. It is believed that the subsequent accumulation of succinate competitively inhibits multiple dioxygenase enzymes that normally suppress hypoxic signaling and demethylate histones and DNA, ultimately leading to increased expression of genes involved in angiogenesis and cell proliferation.

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Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout these phases of activation. In CD4 T cells, T-cell-receptor ligation-along with co-stimulatory and cytokine signals-induces a glycolytic anabolic program that is required for biomass generation, rapid proliferation and effector function.

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Article Synopsis
  • Diabetic gastroparesis often involves a depletion of interstitial cells of Cajal (ICCs), while some diabetic patients experience accelerated gastric emptying (GE), especially when accompanied by obesity and high blood glucose levels.
  • Research using mutant mice revealed that hyperglycemia led to increased proliferation of ICCs and faster GE, possibly due to enhanced signaling pathways involving MAPK1 and MAPK3.
  • Various experimental methods, including breath tests and genetic manipulation, were used to analyze the effects of hyperglycemia on ICCs and their role in gastric motility.
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