Synthesis and spectral characterization of the phenothiazine-thiosemicarbazide probe for the optical solid-state detection of Hg and Cu.

In this study, a phenothiazine-thiosemicarbazide (PTZDS) probe was synthesized and characterized. The synthesized PTZDS probe exhibited a yellow color, with a native fluorescence emission at = 550 nm and = 450 nm. Over other metal ions, the probe exhibited significant selectivity and sensitivity towards Hg and Cu.

Expression of CD44 is associated with aggressiveness in seminomas.

Background: Testicular germ cell tumors (TGCTs) exhibit diverse biological and pathological features and are divided in two main types, seminomas and nonseminomatous germ cell tumors (NSGCTs). CD44 is a cell surface receptor, which is highly expressed in malignancies and is implicated in tumorigenesis affecting cell-matrix interactions and cell signaling.

Methods And Results: Here, we examined the expression of CD44 in tumor cell lines and in patients' material.

The Expression of Serglycin Is Required for Active Transforming Growth Factor β Receptor I Tumorigenic Signaling in Glioblastoma Cells and Paracrine Activation of Stromal Fibroblasts via CXCR-2.

Serglycin (SRGN) is a pro-tumorigenic proteoglycan expressed and secreted by various aggressive tumors including glioblastoma (GBM). In our study, we investigated the interplay and biological outcomes of SRGN with TGFβRI, CXCR-2 and inflammatory mediators in GBM cells and fibroblasts. SRGN overexpression is associated with poor survival in GBM patients.

Synthesis, biological evaluation and investigations of benzotriazole derivatives as potential inhibitors of NIMA related kinase.

In the current study, a novel compound, bis(3-(2-benzo[][1,2,3]triazol-2-yl)-2-(prop-2-yn-1-yloxy)-5-(2,4,4-trimethylpentan-2-yl)phenyl)methane (TAJ1), has been synthesized by the reaction of 6,6'-methylenebis(2-(2-benzo[][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol) (1), propargyl bromide (2) and potassium carbonate. Spectroscopic (FTIR, H-NMR, C-NMR) and single-crystal assays proved the structure of the synthesized sample. XRD analysis confirmed the structure of the synthesized compound, showing that it possesses two aromatic parts linked a -CH carbon with a bond angle of 108.

Discovery of druggable potent inhibitors of serine proteases and farnesoid X receptor by ligand-based virtual screening to obstruct SARS-CoV-2.

The coronavirus, a subfamily of the coronavirinae family, is an RNA virus with over 40 variations that can infect humans, non-human mammals and birds. There are seven types of human coronaviruses, including SARS-CoV-2, is responsible for the recent COVID-19 pandemic. The current study is focused on the identification of drug molecules for the treatment of COVID-19 by targeting human proteases like transmembrane serine protease 2 (TMPRSS2), furin, cathepsin B, and a nuclear receptor named farnesoid X receptor (FXR).

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats.

Introduction: Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.

Material And Methods: Twenty-eight adult male albino Wistar rats were assigned to four groups: a normal control (NC), a PEN group, a NAC group and a PEN+NAC group.

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture.

Purpose: To study the use of ultra-thick human amniotic membrane for management anophthalmic socket contracture.

Methods: A prospective study done at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Thirty-six patients (45 eyelids) were involved.

Brucellar, Pyogenic, and Tuberculous Spondylodiscitis at Tertiary Hospitals in Saudi Arabia: A Comparative Retrospective Cohort Study.

Introduction: Spondylodiscitis is rare yet the most common form of spinal infection. It is characterized by inflammation of the intervertebral disk space and adjacent vertebral body. In Western countries, the incidence of spondylodiscitis is increasing.

A 'turn-off' fluorescence sensor for selective Hg(II) based on phenothiazine derivative.

Given how crucial it is to preserve a human-safe and sustainable environment, the rapid discovery of possibly lethal heavy metals such as Hg(II) has drawn much attention in recent years. A novel sensor, known as (E)-2-((10-octyl-10H-phenothiazin-3-yl)methylene)hydrazine-1-carbothioamide (PTZHC), was synthesized as a fluorescence 'on-off' sensor for Hg ions. Coordination alters organic molecule electron densities, quenching the fluorescence intensity.

Design, Synthesis, Computational Investigations, and Antitumor Evaluation of -Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells.

Nitrogen and sulfur glycosylation was carried out via the reaction of rhodanine () with α-acetobromoglucose under basic conditions. Deacetylation of the protected nitrogen nucleoside was performed with CHONa in CHOH without cleavage of the rhodanine ring to afford the deprotected nitrogen nucleoside . Further, deacetylation of the protected sulfur nucleoside was performed with CHONa in CHOH with the cleavage of the rhodanine ring to give the hydrolysis product .

Synthesis and characterization of phenothiazine sensor for spectrophotometric and fluorescence detection of cyanide.

A sensitive and selective phenothiazine-based sensor (PTZ) has been successfully synthesized. The sensor PTZ displayed specific identification of CN 'turn-off' fluorescence responses with a quick reaction and strong reversibility in an acetonitrile:water (90:10, V/V) solution. The sensor PTZ for detecting CN exhibits the marked advantages of quenching the fluorescence intensity, fast response time (60 s), and low value of the detection limit.

The Impact of TPA Auxiliary Donor and the π-Linkers on the Performance of Newly Designed Dye-Sensitized Solar Cells: Computational Investigation.

The efficiency of the newly designed dye-sensitized solar cells (DSSCs) containing triphenylamine, diphenylamine (TPA), phenothiazine, and phenoxazine as donors and triazine, phenyl with D-D-π-linker-π-(A) architecture has been investigated using density functional theory (DFT) and time-dependent (TD-DFT) methods. These methods were used to investigate the geometrical structures, electronic properties, absorption, photovoltaic properties, and chemical reactivity. Furthermore, the calculated results indicate that different architectures can modify the energy levels of HOMO and LUMO and reduce the energy gap.

Investigate the suitability of g-CN nanosheets ornamented with BiOI nanoflowers for photocatalytic dye degradation and PEC water splitting.

The two-step thermal polymerization and solvothermal approach is used to construct nano heterostructures of FCN and BiOI (bismuth oxeye iodide), both of which are Nobel metal-free materials. This work reports the effect nano-heterostructure on the micro-structural, light absorption capability, PEC properties and pollutant degradation efficiency of the synthesised heterostructures. The addition to that formation of FCN/BiOI nano-heterostructure enhances the solar light absorption.

Characterization of graphene oxide-ziziphus seeds and its application as a hazardous dye removal adsorbent.

The zizphus seeds are considered as a biomaterial residues that has been used for removing of organic industrial waste such as 2-((10-octyl-9,10-dihydroanthracene-2-yl) methylene) malononitrile (PTZS-CN) dye from aqueous solutions utilizing graphene oxide-Ziziphus (GO-Ziziphus). A batch study explored the impacts of various experimental circumstances, including solution pH, initial dye concentration, temperature, and contact time. General order, nonlinear pseudo-first order and pseudo-second order, elvoich model and intraparticiple diffusion were utilized to analyze the kinetic data.

Design, synthesis, molecular modelling and antitumor evaluation of -glucosylated rhodanines through topo II inhibition and DNA intercalation.

In the present study, 5-arylidene rhodanine derivatives , -glucosylation rhodanine , -glucosylation rhodanine , -glucoside rhodanine and -glucosylation 5-arylidene rhodanines were synthesised and screened for cytotoxicity against a panel of cancer cells with investigating the effective molecular target and mechanistic cell death. The anomers were separated by flash column chromatography and their configurations were assigned by NMR spectroscopy. The stable structures of the compounds under study were modelled on a molecular level, and DFT calculations were carried out at the B3LYP/6-31 + G (d,p) level to examine their electronic and geometric features.

Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives.

The unique biological and physicochemical characteristics of biogenic (green-synthesized) nanomaterials (NMs) have attracted significant interest in different fields, with applications in the agrochemical, food, medication delivery, cosmetics, cellular imaging, and biomedical industries. To synthesize biogenic nanomaterials, green synthesis techniques use microorganisms, plant extracts, or proteins as bio-capping and bio-reducing agents and their role as bio-nanofactories for material synthesis at the nanoscale size. Green chemistry is environmentally benign, biocompatible, nontoxic, and economically effective.

Characterization of Date Seed Powder Derived Porous Graphene Oxide and Its Application as an Environmental Functional Material to Remove Dye from Aqueous Solutions.

This study aims to prepare graphene oxide (GO) from raw date seeds (RDSs), considered one of the available agricultural wastes in Saudi Arabia. The preparation method is done by the conversion of date seeds to lignin and then to graphite which is used in a modified Hummer's method to obtain GO. The adsorption of insoluble phenothiazine-derived dye (PTZS) over raw date Seeds (RDSs) as a low-cost adsorbent was investigated in this study.

In Situ Nitrogen Functionalization of 2D-TiCT-MXenes for High-Performance Zn-Ion Supercapacitor.

Zinc (Zn) ion supercapacitors (ZISCs) have attracted considerable attention as a viable energy storage technology because they are cost-effective, safe, and environmentally friendly. However, cathode materials with suitable properties are rare and need to be explored. In this regard, metal carbides (MXenes) are a good choice for capacitive energy storage, but they exhibit low capacitance.

Green Synthesis and Antibacterial Activity of Ag/FeO Nanocomposite Using Extract.

In the study reported in this manuscript, silver/iron oxide nanocomposites (Ag/FeO) were phytosynthesized using the extract of via a green, economical and eco-friendly strategy. The biosynthesized Ag/FeO nanocomposites were characterized using UV-Vis spectrophotometry, FTIR, XRD, TEM, DLS and SEM-EDX analyses. The particulates showed a triangular and spherical morphology having sizes between 25 and 174 nm.

D-Carvone Attenuates CCl-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway.

D-carvone is a natural monoterpene found in abundance in the essential oil of aromatic medicinal plants with a wide range of pharmacological values. However, the impact of D-carvone on liver fibrosis remains unclear. This study aimed to evaluate the anti-fibrotic potential of D-carvone in a rat model of liver fibrosis and to clarify the possible underlying mechanisms.

Synthesis, Characterization and Application of Polypyrrole Functionalized Nanocellulose for the Removal of Cr(VI) from Aqueous Solution.

Heavy metals are toxic substances that pose a real danger to humans and organisms, even at low concentration. Therefore, there is an urgent need to remove heavy metals. Herein, the nanocellulose (NC) was synthesized by the hydrolysis of cellulose using sulfuric acid, and then functionalized using polypyrrole (ppy) through a polymerization reaction to produce polypyrrole/nanocellulose (ppy/NC) nanocomposite.

Magnetic Nitrogen-Doped Porous Carbon Nanocomposite for Pb(II) Adsorption from Aqueous Solution.

We report in the present study the in situ formation of magnetic nanoparticles (FeO or Fe) within porous N-doped carbon (FeO/N@C) via simple impregnation, polymerization, and calcination sequentially. The synthesized nanocomposite structural properties were investigated using different techniques showing its good construction. The formed nanocomposite showed a saturation magnetization (M) of 23.