Metal Oxide Nanoparticles as Efficient Nanocarriers for Targeted Cancer Therapy: Addressing Chemotherapy-Induced Disabilities.

Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness and exacerbate negative effects. Metal oxide nanoparticles (MONPs), such as iron oxide, zinc oxide, and copper oxide, offer a promising solution by enhancing targeted drug delivery, reducing systemic toxicity, and mitigating chemotherapy-induced disabilities like neurotoxicity and cardiotoxicity.

Comparative analysis of antifungal activity of Rhazya stricta ethanolic extracts and biogenic silver nanoparticles against pathogenic fungi.

Rhazya stricta, a perennial shrub native to the Middle East and South Asia, has been used in traditional medicine for various therapeutic purposes, including antimicrobial action. The current study aimed to compare the antifungal properties of 96% and 50% ethanolic extracts of R. stricta leaves and their biogenic silver nanoparticles (AgNPs).

A combined therapy of meropenem-ZnO nanoparticles efficiently eliminates carbapenem-resistant Klebsiella pneumoniae biofilms, with reduced nephrotoxicity (in vitro).

In response to the World Health Organization's research agenda of antimicrobial resistance in human health, this study appraised the antibacterial and antibiofilm synergistic activity of meropenem and ZnO nanoparticles (ZnO-NPs) combination against carbapenem-resistant Klebsiella pneumoniae (CRKP). The minimum inhibitory concentration (MIC) of meropenem in combination was found to be ~1/12 of its MIC alone. The results of microtiter dilution assay showed that the combination was more efficient in reducing the biofilm biomass than meropenem alone or ZnO-NPs alone.

(Microthyriaceae, Microthyriales), a new lignicolous freshwater fungi from a plateau lake in Yunnan Province, China.

Background: Based on unique morphological features and phylogenetic analysis of combined LSU and ITS sequences, is established as the third species in , along with and . All three species of were reported from freshwater habitats in China.

New Information: sp.

Simplex-lattice design and decision tree optimization of endophytic -multi-walled carbon nanotube composite for enhanced methylene blue removal.

This study investigates a novel approach for enhancing methylene blue (MB) removal from water using a composite of endophytic mate and multi-walled carbon nanotubes (MWCNTs). For the first time, a unique combination of simplex-lattice design and decision tree learning algorithm was employed to optimize MB removal. This innovative approach effectively identified the optimal composite ratio of hyphal mate (0.

Versatile properties of Opuntia ficus-indica (L.) Mill. flowers: In vitro exploration of antioxidant, antimicrobial, and anticancer activities, network pharmacology analysis, and In-silico molecular docking simulation.

Opuntia ficus-indica (L.) Mill. has been used in folk medicine against several diseases.

New (Massarinaceae, Dothideomycetes) and (Incertae sedis, Sordariomycetes) species associated with walnut ( L.) in China.

Six collections of ascomycetes were obtained from samples collected from dead branches and leaves of in Guizhou and Yunnan provinces, China. By incorporating multigene phylogenetic analysis (ITS, LSU, , SSU, , ) supplemented by morphological data, we establish two novel species, namely and . In morphology, can be distinguished from by its narrower conidia (13-16 µm vs.

Unveiling multifunctional inhibitors: holistic spectral, electronic and molecular characterization, coupled with biological profiling of substituted pyridine derivatives against , and .

This study delves into the therapeutic potential of a molecule, 3-substituted phenyl-1-(pyridine-4-carbonyl)-1-pyrazole-4-carboxylic acid (PPP), for antimicrobial, antioxidant and anti-diabetic activities. The research encompasses design, synthesis, molecular docking and biological screening of related pyrazole carboxylic acid derivatives. Spectral studies confirmed the structures and molecular mechanics with DFT calculations provided insights into molecular properties and interactions.

Multifaceted chemical and bioactive features of Ag@TiO and Ag@SeO core/shell nanoparticles biosynthesized using L. extract.

Due to increasing concerns about environmental impact and toxicity, developing green and sustainable methods for nanoparticle synthesis is attracting significant interest. This work reports the successful green synthesis of silver (Ag), silver-titanium dioxide (Ag@TiO), and silver-selenium dioxide (Ag@SeO) nanoparticles (NPs) using L. extract.

Assessing the effect of Artemisia sieberi extracts on surface roughness and candida growth of digitally processed denture acrylic materials.

Background: Denture stomatitis, frequently encountered, is generally addressed symptomatically, with limited exploration of preventive approaches involving antifungal medicinal plants.

Objective: This study assessed the impact of Artemisia sieberi extracts on the candida growth of conventional and digitally processed acrylic materials.

Method: Thirty acrylic resin discs (3 mm thickness × 10 mm diameter) were prepared by conventional or CAD/CAM technology (milling and 3D printing).

Turmeric extract-mediated biogenic synthesis of Ag@SeO magnetic nanoparticles: characterization, optimization, antibacterial and antioxidant activities.

This study bio-synthesized Ag@SeO bmNPs successfully, using turmeric ethanol extract, and characterized them using various techniques. The FT-IR analysis reveals the involvement of these plant-derived compounds, especially phenolics, in the reduction process by acting as electron donors and stabilizing/capping agents. Zeta potential analysis showed a slight negative surface charge for the stability of Ag@SeO NPs, where TEM revealed spherical nanoparticles with an average size of 20 nm.

Silver nanoparticles improve the fungicidal properties of Rhazya stricta decne aqueous extract against plant pathogens.

One of the most promising, non-toxic, and biocompatible developments for many biological activities is the green synthesis of nanoparticles from plants. In this work, we investigated the antifungal activity of silver nanoparticles (AgNPs) biosynthesized from Rhazya stricta aqueous extract against several plant pathogenic fungi. UV-visible spectroscopy, Zeta potential analysis, Fourier-transform infrared spectroscopy (FTIR), and transmitted electron microscopy (TEM) were used to analyze the biosynthesized AgNPs.

The Antifungal Activities of Silver Nano-Aggregates Biosynthesized from the Aqueous Extract and the Alkaline Aqueous Fraction of against Some Species.

is a major medicinal species used in indigenous medicinal herbal medications in South Asia, the Middle East, Iran, and Iraq to treat a variety of ailments. The current study aimed to investigate the antifungal properties of biosynthesized silver nanoparticles (AgNPs) made from aqueous extract and its alkaline aqueous fraction. Fourier transform infrared spectroscopy (FTIR), UV-vis spectrophotometry, dynamic light scattering (DLS), and transmitted electron microscopy (TEM) were used to characterize AgNPs.

Morphological, molecular, and histopathological studies on from and its role as an environmental biological indicator.

Pigeons are a cosmopolitan group of birds with abundant and large populations associated with human activities. This study focused on determining parasitic infections within domestic pigeons (). Forty-eight pigeons were examined for infections, of which 29.

Application of artificial neural networks for enhancing lipase synthesis for green biodiesel production.

Biodiesel is a sustainable, and renewable alternative to fossil fuels that can be produced from various biological sources with the aid of lipases. This study developed a simple and novel fungal system for lipase biosynthesis to be used for catalyzing the oily residuals into biodiesel, employing the artificial neural network (ANN), and semi-solid-state fermentation (SSSF). was selected among agro-industrial oily residuals as a substrate for lipase biosynthesis by MH47297.

A Comparative Study of Cr(VI) Sorption by AKW Biomass and Its Extracellular Melanin: Complementary Modeling with Equilibrium Isotherms, Kinetic Studies, and Decision Tree Modeling.

Melanin as a natural polymer is found in all living organisms, and plays an important role in protecting the body from harmful UV rays from the sun. The efficiency of fungal biomass () and its extracellular melanin as Cr(VI) biosorbents was comparatively considered. The efficiency of Cr(VI) biosorption by the two sorbents used was augmented up to 240 min.

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens.

The high prevalence of fungal resistance to antifungal drugs necessitates finding new antifungal combinations to boost the antifungal bioactivity of these agents. Hence, the aim of the present investigation was to greenly synthesize zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract of and investigate their antifungal activity and synergistic efficiency with common antifungal agents. The biofabricated ZnO-NPs were characterized to detect their physicochemical properties.

Surf Redfish-Based ZnO-NPs and Their Biological Activity with Reference to Their Non-Target Toxicity.

The marine environment is a rich source of bioactive compounds. Therefore, the sea cucumber was isolated from the Red Sea at the Al-Ain Al-Sokhna coast and it was identified as surf redfish (). The aqueous extract of the surf redfish was utilized as an ecofriendly, novel and sustainable approach to fabricate zinc oxide nanoparticles (ZnO-NPs).

Biological Activity of Biosynthesized Silver Nanoaggregates Prepared from the Aqueous Extract of against spp.

is commonly used in folk medicine for the treatment of nervous and gastrointestinal disturbances and other medical issues because of its potent antioxidant capacity. The current study evaluated the anti-candida effects of silver nanoparticles (AgNPs) synthesized from an aqueous extract of against different spp. The aqueous extract was prepared from the fresh leaves of .

Silver Nanoparticles of Extracts: Chemical Composition and Antimicrobial Activities.

Background: (mugwort) is a member of the daisy family Asteraceae and is widely propagated in Saudi Arabia. has historical medical importance in traditional societies. The current study aimed to assess the antibacterial and antifungal characteristics of the aqueous and ethanolic extracts of .

Green Biofabrication of Silver Nanoparticles of Potential Synergistic Activity with Antibacterial and Antifungal Agents against Some Nosocomial Pathogens.

Nosocomial bacterial and fungal infections are one of the main causes of high morbidity and mortality worldwide, owing to the high prevalence of multidrug-resistant microbial strains. Hence, the study aims to synthesize, characterize, and investigate the antifungal and antibacterial activity of silver nanoparticles (AgNPs) fabricated using leaves against nosocomial pathogens. The biogenic AgNPs revealed a small particle diameter of 35.