Exploring the osteogenic potential of semisynthetic triterpenes from Combretum leprosum: An in vitro and in silico study.

Combretum leprosum Mart. is a plant of the Combretaceae family, widely distributed in the Northeast region of Brazil, popularly used as an anti-inflammatory agent, and rich in triterpenes. This study evaluated in vitro and in silico potential osteogenic of two semisynthetic triterpenes (CL-P2 and CL-P2A) obtained from the pentacyclic triterpene 3β,6β,16β-trihydroxylup-20(29)-ene (CL-1) isolated from C.

The Neonatal Palliative Care Attitude Scale: Psychometric properties for Portuguese neonatal nurses.

Background: This study is aimed to perform the translation and cultural adaptation of the Neonatal Palliative Care Attitude Scale (NiPCAS) and evaluation of its psychometric properties with Portuguese neonatal nurses.

Methods: The research started with a scoping review that allowed the identification of the NiPCAS. It was a methodological study with a quantitative approach.

Tidal variability of water quality parameters in a mesotidal estuary (Sado Estuary, Portugal).

To establish effective water quality monitoring strategies in estuaries, it is imperative to identify and understand the main drivers for the variation of water quality parameters. The tidal effect is an important factor of the daily and fortnightly variability in several estuaries. However, the extent of that influence on the different physicochemical and biological parameters is still overlooked in some estuarine systems, such as the Sado Estuary, a mesotidal estuary located on the west coast of Portugal.

Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions.

Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems.

The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats.

Zoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the concentration of 0.

Bisphosphonate-related osteonecrosis induced change in alveolar bone architecture in rats with participation of Wnt signaling.

Objective: This work aimed to study the role of inflammation in medication-related osteonecrosis of the jaw (MRONJ) in rats with focus on Wnt signaling.

Methods: A total of 36 female Wistar rats (12 weeks ± 200 g) were divided into 2 groups (n = 6) in 3 experiments: saline (SAL) and zoledronic acid (ZOL). For MRONJ induction, rats received 0.

DISABKIDS® in Brazil: advances and future perspectives for the production of scientific knowledge.

Objective: to map the Brazilian scientific production related to the stages of the methodological process for the use of DISABKIDS® instruments and/or forms adapted to Brazil.

Method: scoping review, with searches conducted on10 electronic databases, plus Google Scholar and contacts with researchers, without restriction of period or language.

Results: the mapping identified 90 scientific studies involving 46 instruments.

Anti-inflammatory activity of herb products from Licania rigida Benth.

Purpose: The objective of the present study was to evaluate the systemic anti-inflammatory activity of the hydroalcoholic extract of the leaves of Licania rigida Benth (EHFLR) on models of systemic inflammation in mice.

Methods: The quantitative chemical profiles of phenolic acids and flavonoids were performed by High-Performance Liquid Chromatography (HPLC). Systemic anti-inflammatory activity was determined from carrageenan and dextran-induced paw edema models and the animals were orally treated (p.

Pain from the life cycle perspective: Evaluation and Measurement through psychophysical methods of category estimation and magnitude estimation.

Objective: to describe acute and chronic pain from the perspective of the life cycle.

Methods: participants: 861 people in pain. The Multidimensional Pain Evaluation Scale (MPES) was used.

Pain intensity, disability and depression in individuals with chronic back pain.

Objectives: to measure the pain intensity, identify the disability and depression levels in people with chronic back pain and to correlate these variables. A cross-sectional, descriptive and exploratory study was undertaken at the Pain Treatment Clinic of the University of São Paulo at Ribeirão Preto Hospital das Clínicas, between February and June 2012, after receiving approval from the Ethics Committee at the University of São Paulo at Ribeirão Preto College of Nursing.

Method: sixty subjects with chronic back pain participated.

Evaluation of the perception of chronic ischemic pain in humans with peripheral arterial disease.

The perception of pain is multidimensional, subjective, and unique to each individual and can be influenced by several dimensions of pain. The objective of this study was to evaluate the perception of chronic ischemic pain using the descriptors of pain and to rate the main descriptors of chronic pain to people with peripheral arterial disease (PAD). The study was conducted in two hospitals in Brazil and consisted of two phases.

Pain management at inpatient wards of a university hospital.

Background And Objectives: This is an exploratory, descriptive and transversal study aiming to determine the prevalence, characterization, location, and measurement and discuss pharmacological analgesic measures for acute pain management in five inpatient wards of a university hospital.

Method: We enrolled 856 subjects in the study, of whom 272 were in pain at the time. Information related to pain was obtained using a bedside structured interview.

[Influence of treatments for migraine on quality of life: literature integrative review].

This study aimed to identify the impact of the main treatments for migraine on the quality of life (QOL) as affected people and the instruments used to assess the QOL. It consists of an integrative review of the literature, in which the databases PubMed, BIREME and The Cochrane Library were used, considering articles from 2000 to 2009. We selected 42 articles for analysis, which were fully read.

Lumbar epidural anesthesia in the treatment of discal lombosciatalgia: a comparative clinical study between methylprednisolone and methylprednisolone with levobupivacaine.

Background And Objectives: Lumbar epidural technique has been used in the treatment of lombosciatalgia since 1953. In most cases, methylprednisolone is used along with a local anesthetic, and it is not known whether the isolated use of methylprednisolone is equally effective in relieving symptoms. The objective of this study was to compare the efficacy of two different solutions--methylprednisolone with saline and methylprednisolone with levobupivacaine injected in the epidural space to heal lombosciatalgia secondary to lumbar herniated disk.

Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy.

The aim of this study was to evaluate the occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and polymerase chain reaction (PCR).

The prevalence and characterization of self-medication for obtaining pain relief among undergraduate nursing students.

This study investigates the prevalence of self-medication among undergraduate nursing students seeking to relieve pain and characterizes the pain and relief obtained through the used medication. This epidemiological and cross-sectional study was carried out with 211 nursing students from a public university in Goiás, GO, Brazil. A numerical scale (0-10) measured pain intensity and relief.

Evaluation of the quality of life of clients with chronic ischemic pain.

The evaluation of quality of life (QOL) faced with chronic ischemic pain involves the clients in their subjectivity and multidimensionality. This descriptive study aimed to evaluate the quality of life of clients who presented chronic ischemic pain. A total of 100 clients of hospital institutes participated in the study.

Multidimensional pain evaluation scale.

This study developed a pain evaluation scale and validated it for the Portuguese language. Development of the inventory--308 readily available pain descriptors--were searched in international literature and validated by six judges. One hundred descriptors of acute pain and 100 descriptors of chronic pain were found, which were used in the next stage.

Developing a comparative scale of different nociceptive and neuropathic pain through two psychophysical methods.

The general aim of this study was to create a comparative scale of different types of pain through different psychophysical methods and different samples. The psychophysical methods used were magnitude estimation and category estimation. The participants were 30 patients from different outpatient clinics, 30 physicians and 30 nurses.

Validation of the ratio scale of the differents types of pain.

The main aim was to validate the ratio scale derived from the non-metric continuum of the intensity of the different types of pain using cross-modality matching. Magnitude estimation method and cross-modality matching were used with perceived line lengths. The study was formed by 30 outpatients from various specialty clinics, 30 physicians and 90 nurses.

Categorization of postoperative pain descriptors in the sensitive, affective and evaluative dimensions of painful experiences.

The main purpose of this study was categorizing 20 descriptors of post-operative pain sensory, affective and evaluative dimensions. Sixty-one physicians participated. They were between 24 and 63 years old and categorized 20 descriptors by considering their level of attribution in the description of post-operative pain sensory, affective and evaluative qualities.

Psychophysical evaluation of the descriptors of pain in the postoperative.

This experimental study aimed to evaluate 20 descriptors of the post-operative pain considering the adequate level of each in describing it. A total of 48 post-operated patients, age between 14 and 70 years old, 60.4% male, participated in the experiment.