Medullary Thyroid Carcinoma in the Background of Non-neoplastic Toxic Nodular Goiter.

Background/objective: Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.

Case Report: We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.

Ameliorating effects of natural herbal supplements against water-borne induced toxicity of heavy metals on Nile tilapia, (Oreochromis niloticus).

The efficacy of herbal supplements in mitigating heavy metals (HMs) toxicity was investigated using a widely grown fish, the Nile tilapia (Oreochromis niloticus). The experiment was conducted over two phases: during the stress phase, the experimental fishes were exposed to sub-lethal concentrations of HMs, including lead, cadmium, zinc, and copper for 15 days; following which during the feeding phase, herbal supplements were given for 70 days to ameliorate their effects. Seven groups were established: the control negative group (CON-ve), control positive group (CON+ve, without any treatment), and five groups with supplementation of 1% turmeric (TUR), cinnamon (CIN), ginger (GIN), garlic (GAR), and their mixture (MIX), respectively.

Why do nurses leave their jobs? Understanding person-related hostility in the healthcare sector of Pakistan.

Nursing is considered indigent and oppressed because of uneven organizational hierarchies and unsatisfactory work environments. This study aimed to highlight the critical aspects of organizational culture in the nursing profession and, in general, those propagating hostile behaviours among female nursing staff that result in dissatisfaction and intention to leave the organization. A quantitative research approach was applied and a survey research strategy was used to collect the data.

Geospatial quality assessment of locally available ice for heavy metals and metalloids and their potential risks for human health in Karachi, Pakistan.

Extreme hot conditions during summers, high poverty rate and continuous electricity load shedding affect commercial manufacturing and sale of ice in many countries. The vendors prepared ice using untreated piped water, tanker water and ground water. These waters may contain hazardous pollutants and ice made from them will pose a potential human health risk.

Enhanced Electrochemical Performance of MWCNT-Assisted Molybdenum-Titanium Carbide MXene as a Potential Electrode Material for Energy Storage Application.

Two-dimensional (2D) materials such as MXenes have attracted considerable attention owing to their enormous potential for structural flexibility. Here, we prepared a MoTiCT-layered structure from parent MoTiAlCT MAX by chemically selective etching of the aluminum layer. The prepared MXene was employed in composite formation with CTAB-grafted multiwalled carbon nanotubes (MWCNTs) to have a structure with improved electrochemical performance.

Evaluating Glycemic Control Efficacy and Safety of the Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis.

Introduction: Diabetes Mellitus (DM) is a significant global health concern, with Type 2 DM (T2DM) being highly prevalent. Glucagon-Like Peptide 1 receptor agonists (GLP-1RA), such as Danuglipron, offer potential benefits in T2DM management. This meta-analysis examines the safety and efficacy of Danuglipron, focusing on adverse outcomes and glycemic parameters.

Optimized time dependent exfoliation of graphite for fabrication of Graphene/GO/GrO nanocomposite based pseudo-supercapacitor.

High capacitance devices (Supercapacitors) fabricated using two-dimensional materials such as Graphene and its composites are attracting great attention of the research community, recently. Synthesis of 2D materials and their composites with high quality is desirable for the fabrication of 2D materials-based supercapacitors. Ultrasonic Assisted Liquid Phase Exfoliation (UALPE) is one of the widely used techniques for the synthesis of graphene.

Comparative Study between Sulfurized MoS from Molybdenum and Molybdenum Trioxide Precursors for Thin-Film Device Applications.

Two-dimensional (2D) materials have been studied as an emerging class of nanomaterials owing to their attractive properties in nearly every field of science and technology. Molybdenum disulfide (MoS) is one of the more promising candidates of these atomically thin 2D materials for its technological potential. The facile synthesis of MoS remains a matter of broad interest.

Synergetic Catalytic and Photocatalytic Performances of Tin-Doped BiFeO/Graphene Nanoplatelet Hybrids under Dark and Light Conditions.

Because of a rapidly growing need for water, it is essential to find new fast and reliable ways of water purification from organic pollutants. For removing organic azo dyes from water, various catalysts and photocatalysts have been designed to meet crucial water needs. In this study tin (Sn) doped bismuth ferrite (BFO) nanoparticles have been synthesized using the sol-gel technique.

Efficacy of marigold (Tagetes erecta L.) for the treatment of tannery and surgical industry wastewater under citric acid amendment: a lab scale study.

Contamination of land and aquatic ecosystems with heavy metals (HMs) is a global issue having the persistent potential to damage the quality of food and water. In the present study, Tagetes erecta L. plants were used to assess their potential to uptake HMs from wastewater.

Examine the parenting style effect on the academic achievement orientation of secondary school students: The moderating role of digital literacy.

The purpose of the study was to determine the association between parenting styles (authoritative and permissive) and students' self-efficacy (LSE), self-regulatory learning (SRL), and academic accomplishment orientation of secondary school students in Punjab, Pakistan. The study also investigated the effect of digital learning as a moderating variable in the relationship between SRL and academic achievement oriented, as well as between learner self-efficacy (LSE) and academic achievement among secondary school students. The study was conducted with ( = 720) secondary school students of Punjab Pakistan.

Association Between Helicobacter pylori Infection and Serum Iron Profile.

Introduction: Helicobacter pylori (H. pylori) infection is reported to be the most frequent cause of morbidity and mortality in cases of upper gastrointestinal (GI) diseases. There is paucity of research between the possible association of H.

Impact of Coronavirus Diseases on Liver Enzymes.

Introduction Coronavirus disease 2019 (COVID-19) affects various organs including lungs, brain, and eyes. Very limited data is available related to the effect of COVID-19 on liver. This study is conducted to determine the impact of COVID-10 on liver by measuring the frequency of participants with deranged liver enzymes in patients diagnosed with COVID-19.

Acute Generalized Exanthematous Pustulosis Induced by Cetuximab.

A wide variety of diseases and drugs can cause cutaneous pustular eruptions. Acute generalized exanthematous pustulosis (AGEP) is a unique drug-induced dermatosis clinically presented as erythematous papular and pustular eruption, usually caused by certain systemic drugs. We are presenting a very rare association of AGEP with a biological agent, cetuximab.

Acceptance of COVID-19 Vaccine in Pakistan: A Nationwide Cross-Sectional Study.

Introduction The coronavirus disease 2019 (COVID-19) vaccine is available across various countries worldwide, with public-private partnerships ensuring all individuals are vaccinated through a phased approach. Irrespective of the geographical spread, several myths pertaining to the COVID-19 vaccine have stemmed, ultimately limiting the national administration of vaccines and rollouts. This study assessed the acceptance of the COVID-19 vaccine among the general public in Pakistan.

In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations.

The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world after December 2019, jeopardize the prevailing health system in the world and has raised serious concerns about human safety. Multi-directional efforts are made to design small molecule inhibitors, and vaccines and many other therapeutic options are practiced, but their final therapeutic potential is still to be tested. Using the old drug or vaccine or peptides could aid this process to avoid such long experimental procedures.

Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients.

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020.

Comparison of Incidence of Myocardial Infarction in Patients With Rheumatoid Arthritis and Diabetes Mellitus.

Introduction Patients with rheumatoid arthritis (RA) have a higher risk of cardiovascular diseases (CVDs) when compared to the general population, with most deaths attributed to myocardial infarctions (MI). However, patients with RA do not get the same attention in terms of cardiovascular screening as compared to other diseases, like diabetes mellitus (DM). Therefore, this study aims to compare the risk of CVD among patients with RA and DM.

Experimental and Computational Analysis of MnO@VC-MXene for Enhanced Energy Storage.

Herein, we studied the novel and emerging group of 2D materials namely MXene along with its nanocomposites. This work entails detailed experimental as well as computational study of the electrochemical behavior of vanadium carbide (VCT) MXene and MnO-VC nanocomposite with varying percentages of MnO. A specific capacitance of 551.

Evaluating data-driven methods for short-term forecasts of cumulative SARS-CoV2 cases.

Background: The WHO announced the epidemic of SARS-CoV2 as a public health emergency of international concern on 30th January 2020. To date, it has spread to more than 200 countries and has been declared a global pandemic. For appropriate preparedness, containment, and mitigation response, the stakeholders and policymakers require prior guidance on the propagation of SARS-CoV2.

Prevalence of Irritable Bowel Syndrome and Frequency of Symptoms in the General Population of Pakistan.

Introduction: Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder. Risk factors include infective enteritis, female sex, antibiotic exposure, anxiety, and depression. The aim of this study is to find out the prevalence of IBS in healthy population and determine the characteristics of symptoms.

MR Product as a Novel Diagnostic Indicator for Chronic Secondary Mitral Regurgitation.

Background Chronic secondary mitral regurgitation (SMR) is a common form of valvular heart disease. Its diagnosis through echocardiography is challenging and dependent on subjective interpretations. The subjective error to diagnose SMR can be reduced by developing accurate predictive quantitative parameters that support echocardiographic interpretations and clinical manifestations.

Efficacy of fenugreek plant for ascorbic acid assisted phytoextraction of copper (Cu); A detailed study of Cu induced morpho-physiological and biochemical alterations.

Phytoremediation via phyto-extraction is well recognized and sustainable principle for the economical removal of heavy metals from contaminated water and soil. The twofold objective of the present research work was to investigate the remediation potential of fenugreek for Cu under the influence of ascorbic acid (AA). The effect of copper-ascorbic acid chelation on the growth regulation of fenugreek (Trigonella foenum-graceum L.

Nb-Doped MXene With Enhanced Energy Storage Capacity and Stability.

MXenes present unique features as materials for energy storage; however, limited interlayer distance, and structural stability with ongoing cycling limit their applications. Here, we have developed a unique method involving incorporating Nb atoms into MXene (TiC) to enhance its ability to achieve higher ionic storage and longer stability. Computational analysis using density functional theory was performed that explained the material structure, electronic structure, band structure, and density of states in atomistic detail.