Publications by authors named "Fatima Moghani Ghoroghi"
Article Synopsis
- Seladin-1 (DHCR24) is a gene linked to Alzheimer’s disease, found to be down-regulated in affected brain regions, and may be sourced from hair follicle stem cells (HFSC) with neurogenic potential.
- The study involved culturing HFSC from male Wistar rats, monitoring seladin-1 expression through various methods including immunocytochemistry and real-time PCR from days 8 to 14.
- Results showed increasing seladin-1 expression from days 9 to 11, suggesting its relevance in HFSC development, and concluded that HFSC could hold potential for future cell therapy in Alzheimer’s disease.
Background: Alzheimer's disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model.
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