Publications by authors named "Fatima Hariss"
Background: Intraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as , a widespread parasite which infects the gut epithelium. IFN-γ producing CD4 T IELs provide an efficient and a long-term protection against cryptosporidiosis while intraepithelial type 1 innate lymphoid cells limits pathogen spreading during early stages of infection in immunodeficient individuals. Yet, the role of T-cell like innate IELs, the most frequent subset of innate lymphocytes in the gut, remains unknown.
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- Type 1 Innate lymphoid cells (ILC1) are found in higher numbers in the inflamed mucosa of Crohn's disease patients, but their specific role in the disease is not well understood.
- A study by Jowett et al. used intestinal organoids to investigate ILC1's functions and discovered that they promote intestinal epithelial growth and tissue remodeling.
- This promotion occurs through a mechanism involving transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.