Short-term aromatase inhibition induces prostatic alterations in adult wistar rat: A biochemical, histopathological and immunohistochemical study.

Purpose: This study aimed to evaluate the effects of estrogen reduction on amyloid deposition, some lipid metabolism and oxidative stress markers, PSA-like production and p63 expression in the prostate of the adult rat.

Methods: Aromatase inhibitor: Formestane (4-OHA), was administrated to male rats, at a dose of 0.1 mg/kg b.

Effects of colocynth alkaloids and glycosides on Wistar rats fed high-fat diet. A biochemical and morphological study.

Introduction: In traditional medicine, Citrullus colocynthis is used to treat diabetes, hyperlipidemia, cardiovascular diseases, inflammation, and oxidative stress, all of which can appear when a diet rich in vegetable fats, such as palm oil, is continuously consumed. Such high-fat diets are chronic stressors of the hypothalamic-pituitary-adrenal axis. The objective of our study was to analyze and evaluate the effects of colocynth total alkaloids and glycosides on metabolic, hormonal, and structural disorders of the adrenal medulla in Wistar rats fed a high-fat diet.

Effects of thyroxine treatment during lactation on the testicular function of rats across different ages.

Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition.

[Evaluation of androstenedione adrenal content and effects of castration on the domestic rabbit (Oryctolagus cuniculus)].

DHEA, DHEA sulphate and androstenedione are C19 steroïds secreted by the adrenal cortex. These hormones with a weak androgen activity are precursors of estrogens and androgens. In human and other primates these hormones are produced in important quantities, even though, in domestic and laboratory animals, a few secretion is measured.

POSVP(21), a major secretory androgen-dependent protein from sand rat seminal vesicles, identified as a transgelin.

The seminal vesicles of adult sand rat contain a major secretory protein band (MW 21 kDa) designated as Psammomys obesus seminal vesicles protein of 21 kDa (POSVP(21)). This protein is abundant in secretions, regulated by androgens and also present in the vaginal plug. POSVP(21) accounts for over 22.