Unveiling the phytochemical profile, antioxidant and antibacterial activities, acute toxicity insight and analgesic effect of stems: An unexplored endemic plant from Morocco.

is an endemic shrubby leguminous plant of Morocco used in traditional folk medicine. The plant has never been studied for either its phytochemical or pharmacological properties. This study represents the first investigation of the phytochemical profile as well as the antioxidant, the antibacterial, the analgesic effects and the oral acute toxicity of .

Ultra-High-Performance Liquid Chromatography with Photodiode Array and High-Resolution Time-of-Flight Mass Spectrometry Detectors (UHPLC-PDA-ESI-ToF/HRMS) for the Tentative Structural Characterization of Bioactive Compounds of Extracts in Relation to Their Biological Activities.

Background: of the family is a Mediterranean plant widely used in the Moroccan traditional folk medicine. The aim of this work was to explore the phytochemical composition of extracts and its antioxidant activity.

Methods: Separation and identification of the major phytochemicals present in the two hexane and ethyl acetate explored extracts have been achieved through ultra-high-performance liquid chromatography separation technique coupled to photodiode array and high-resolution time-of-flight mass spectrometry detectors.

Health Benefits and Pharmacological Aspects of Chrysoeriol.

A flavone, chrysoeriol is synthetized in several plant species. It comes from several natural sources, especially medicinal plants. The identification and isolation of this compound has been carried out and verified by several research teams using different spectral methods.

Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry, and investigations, mechanism insights, clinical evidences and perspectives.

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial, anticancer, antidiabetic, analgesic, and anti-inflammatory effects, which are related to the presence of numerous bioactive compounds, including phenolic acids, flavonoids, and terpenoids. In the present review, we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal plants. The in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes, whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental models.

Natural Bioactive Compounds from Medicinal Plants as Antibacterial Drugs: Mechanism Insights and Clinical Perspectives.

The coevolution in microbes has generated major functional consequences leading bacteria to develop resistance to antibiotics. Indeed, bacterial strains have been able to develop and adapt to the action of antibiotics via several resistance mechanisms. In this context, researchers are currently conducting many studies to screen natural antibacterial substances such as secondary metabolites of medicinal plants.

Genetic diversity, antimicrobial, nutritional, and phytochemical properties of Chenopodium album: A comprehensive review.

Chenopodium album L., is a medicinal plant widely cultivated in Europe, North America, Iran, South Africa, Australia, South America, and Asia. This species is commonly used in folk medicine to treat many diseases such as cancer, viral infections, parasitic diseases, gastrointestinal disorders, as well as bacterial and fungal infections.

Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants.

Plants and microbes interact with each other via different chemical signaling pathways. At the risophere level, the microbes can secrete molecules, called elicitors, which act on their receptors located in plant cells. The so-called elicitor molecules as well as their actions differ according to the mcirobes and induce different bilogical responses in plants such as the synthesis of secondary metabolites.

Phytochemistry, Toxicology, and Pharmacological Properties of .

L. is an endemic aromatic and medicinal plant. This work reports previous studies on concerning its taxonomy, botanical description, geographical distribution, bioactive compounds, toxicology, and biological effects.

Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn.

Ethnopharmacological Relevance: Centaurium erythraea is an important medicinal plant in many countries, e.g. Morocco, Algeria, Italy, Spain, Portugal, and countries of Balkan Peninsula.

Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Daphne gnidium: A review.

Ethnopharmacological Relevance: Daphne gnidium L., (Lazaz or Metnan) is a perennial plant that grows around the Mediterranean basin, in Southern Europe, North Africa and the Middle East. It is used in different countries for hair care and to treat several diseases including skin cancer, diabetes, nervous breakdowns, sinusitis, poisoning, rheumatic disorders, odontalgia, muscular pain, and gastrointestinal infections.

Phytochemical and biological activities of Pinus halepensis mill., and their ethnomedicinal use.

Ethnopharmacological Relevance: Pinus halepensis Mill., is a Mediterranean medicinal plant with numerous traditional applications such as anti-scarring, antiseptic, astringent, antifungal, and anti-tuberculosis. It is used against diarrhea, wounds, rheumatism, cough, gastrointestinal illnesses, hypertension, and hemorrhoids.

Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L.

Ethnopharmacological Relevance: Origanum majorana L., is an aromatic and medicinal plant distributed in different parts of Mediterranean countries. This species is widely used in traditional medicine for the treatment of many diseases such as allergies, hypertension, respiratory infections, diabetes, stomach pain, and intestinal antispasmodic.

Ethnomedicinal use, phytochemistry, pharmacology, and food benefits of Thymus capitatus.

Ethnopharmacological Relevance: Thymus capitatusHoffm. et Link. is an endemic medicinal plant to the Mediterranean region.

Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.,) schreb.

Ethnopharmacological Relevance: Ajuga iva (L.,) Schreb (A. iva).

Structural characterization of bioactive compounds in Cotula cinerea extracts by ultra-high-performance liquid chromatography with photodiode array and high-resolution time-of-flight mass spectrometry detectors.

Rationale: Cotula cinerea of the Asteraceae family is a traditional Moroccan plant with various biological activities such as analgesic, cytotoxic and antioxidant effects which are often related to the presence of secondary metabolites. The present work aims to screen and identify the main phytochemicals compounds of Cotula cinerea extracts.

Methods: A method was developed that coupled a rapid and simple ultra-high-performance liquid chromatography system with both photodiode array and high-resolution time-of-flight mass spectrometry detectors (UHPLC-PDA/TOF-HRMS) for the identification of the main secondary metabolites of three investigated extracts (hexane, AcOEt and n-BuOH).

Cytotoxicological Investigation of the Essential Oil and the Extracts of and from Morocco.

The objective of this work was to investigate the cytotoxicological effect of the extracts (hexane, ethyl acetate, and -butanol) of and in addition to the essential oil of . These plants are widely used in the Moroccan traditional folk medicine. The cytotoxic effect was explored against two cancer cell lines, Vero and RD, using the colorimetric MTT assay.