Publications by authors named "Fatima Benkouka"
Article Synopsis
- Hyperhomocyteinemia (HHcy) is linked to increased risk of coronary artery disease (CAD), and specific genetic mutations in MTHFR, MTR, and MTRR impact homocysteine levels.
- CAD patients displayed significantly higher total homocysteine levels compared to controls, with smokers also showing elevated levels and a greater risk for CAD.
- The MTHFR 1298C allele was more common in CAD patients and associated with risk for HHcy, while no significant differences were found for other mutations in MTR and MTRR.
Background: Elevated plasma total homocysteine (tHcy) is increasingly being recognized as a risk factor for coronary artery disease (CAD) and other defects. Recent genetic studies have characterized molecular determinants contributing to altered homocysteine metabolism. Our objectives were therefore to confirm the relationship of tHcy with CAD and to examine the importance of genetic influence on tHcy in the coronary angiograms and conventional cardiovascular risk factors recorded in 230 subjects.
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