Survival Outcomes of Patients with Primary Plasma Cell Leukemia in the Era of Proteasome Inhibitors and Immunomodulatory Agents: A Real-Life Multicenter Analysis.

Objective: In this study, we aimed to obtain real-life data on the use of antimyeloma agents, which significantly increase overall survival (OS) in multiple myeloma (MM) patients, in primary plasma cell leukemia (pPCL) patients with poor prognosis.

Materials And Methods: Data from 53 patients who were diagnosed with pPCL between 2011 and 2020 and who used at least one proteasome inhibitor (PI) and/or immunomodulatory (IMID) agent were analyzed retrospectively. Depending on the year of the pPCL diagnosis, 20% leukocytes or ≥2x10/L plasma cells in the peripheral blood was used as a diagnostic criterion.

Eltrombopag treatment in thrombocytopenia following hematopoietic stem cell transplantation: A multicenter real-world experience.

Introduction: Thrombocytopenia is among the most common complications following hematopoietic stem cell transplantation and is associated with increased mortality and morbidity with no standard treatment yet. In this multicenter and retrospective study, we aim to present our multi-center experience of Eltrombopag treatment in patients with isolated thrombocytopenia following HSCT.

Material-method: A total of 73 patients from 5 centers who underwent autologous or allogeneic stem cell transplantation, had no primary disease relapse, all of whom had neutrophil engraftment, complete chimerism, and who were diagnosed with Prolonged Isolated Thrombocytopenia (PIT) or Secondary Failure Of Platelet Recovery (SFPR) were included in the study.

Investigation of the effect of the career management system and succession plan on employees' work stress and feelings of entrapment.

Background: Work stress and feeling of entrapment are harmful physical and emotional results for employees when the workload demands exceed their capacities.

Objective: This study aims to investigate the effects of the career management system and succession plan on employees' work stress and feelings of entrapment in hopes of improving employees' well-being to promote business continuity.

Methods: In this cross-sectional study, the convenient sampling method was adopted.

An Examination of the Digital Parenting Profiles in Turkey.

Internet use among children is increasing. This requires parents to develop digital parenting competencies as they are responsible for their children's well-being. In the current study the digital parenting self-efficacy perceptions of Turkish parents are examined with regard to the parental role, educational status, age, number of children, and Internet use experiences.

Guided acoustic Brillouin scattering measurements in optical communication fibers.

Guided acoustic Brillouin (GAWBS) noise is measured using a novel, homodyne measurement technique for four commonly used fibers in long-distance optical transmission systems. The measurements are made with single spans and then shown to be consistent with separate multi-span long-distance measurements. The inverse dependence of the GAWBS noise on the fiber effective area is confirmed by comparing different fibers with the effective area varying between 80 µm and 150 µm.

Serum amphiregulin and cerebellin-1 levels in severe preeclampsia.

Purpose: Preeclampsia is a form of hypertensive disorders of pregnancy and defined as the presence of new-onset hypertension and proteinuria or other end organ damage occurring after 20-week gestation. Preeclampsia can be a destructive process that can cause maternal and infant mortality. The exact etiopathogenesis of preeclampsia is still undefined.

Field and lab experimental demonstration of nonlinear impairment compensation using neural networks.

Fiber nonlinearity is one of the major limitations to the achievable capacity in long distance fiber optic transmission systems. Nonlinear impairments are determined by the signal pattern and the transmission system parameters. Deterministic algorithms based on approximating the nonlinear Schrodinger equation through digital back propagation, or a single step approach based on perturbation methods have been demonstrated, however, their implementation demands excessive signal processing resources, and accurate knowledge of the transmission system.

30Tb/s C- and L-bands bidirectional transmission over 10,181km with 121km span length.

We demonstrated the first 30Tb/s (350 × 85.74Gb/s) optical transmission over 10,181km using bidirectional C/L-bands, 121.2km hybrid fiber spans, DP-QPSK modulation and EDFAs.

Mode-division multiplexed transmission with inline few-mode fiber amplifier.

We demonstrate mode-division multiplexed WDM transmission over 50-km of few-mode fiber using the fiber's LP01 and two degenerate LP11 modes. A few-mode EDFA is used to boost the power of the output signal before a few-mode coherent receiver. A 6×6 time-domain MIMO equalizer is used to recover the transmitted data.

Experimental study of non-binary LDPC coding for long-haul coherent optical QPSK transmissions.

The performance of rate-0.8 4-ary LDPC code has been studied in a 50 GHz-spaced 40 Gb/s DWDM system with PDM-QPSK modulation. The net effective coding gain of 10 dB is obtained at BER of 10(-6).

10 x 112Gb/s PDM-QPSK transmission over 5032 km in few-mode fibers.

Few-mode fibers (FMFs) are used for the first time to transmit over 5000 km. Ten WDM channels with 50GHz channel spacing at 112 Gb/s per channel using PDM-QPSK are launched into the fundamental mode of the FMFs by splicing single-mode fibers directly to the FMFs. Even though few-mode fibers can support an additional spatial mode LP(11) at 1550 nm, the signal remains in the fundamental mode and does not experience mode coupling throughout fiber transmission.

Efficient compensation of inter-channel nonlinear effects via digital backward propagation in WDM optical transmission.

An advanced split-step method is employed for the digital backward-propagation (DBP) method using the coupled nonlinear Schrodinger equations for the compensation of inter-channel nonlinearities. Compared to the conventional DBP, cross-phase modulation (XPM) can be efficiently compensated by including the effect of the inter-channel walk-off in the nonlinear step of the split-step method (SSM). While self-phase modulation (SPM) compensation is inefficient in WDM systems, XPM compensation is able to increase the transmission reach by a factor of 2.

Long distance transmission in few-mode fibers.

Using multimode fibers for long-haul transmission is proposed and demonstrated experimentally. In particular few-mode fibers (FMFs) are demonstrated as a good compromise since they are sufficiently resistant to mode coupling compared to standard multimode fibers but they still can have large core diameters compared to single-mode fibers. As a result these fibers can have significantly less nonlinearity and at the same time they can have the same performance as single-mode fibers in terms of dispersion and loss.

Control of four-wave mixing phase-matching condition using the Brillouin slow-light effect in fibers.

All-optical control of the phase-matching condition in four-wave mixing (FWM) processes is demonstrated using the Brillouin slow-light effect in optical fibers. A counterpropagating stimulated Brillouin scattering (SBS) pump has been used to control the phase velocity of the FWM pump in a wavelength conversion scheme. Both experimental results and theoretical simulations show an SBS-controlled 20 dB difference on the wavelength conversion efficiency.