Preparation and Optimization of Fast-Disintegrating Tablet Containing Naratriptan Hydrochloride Using D-Optimal Mixture Design.

Optimization of a lyophilized fast-disintegrating tablet (LFDT) formulation containing naratriptan hydrochloride, an antimigraine drug, was the foremost objective of the study, aiming in achieving fast headache pain relief. The Design-Expert® v10 software was used to generate formulations using D-optimal mixture design with four components: gelatin (X), hydrolyzed gelatin (X), glycine (X), and mannitol (X) of total solid material (TSM) w/w. The effect of the relative proportion of each component was determined on friability (Y), hardness (Y), and in vitro disintegration time (Y), which was then applied for formulation optimization.