Publications by authors named "Fathima Fazla"
Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults in the intensive care unit with suspected hypoxic ischaemic encephalopathy following a cardiac arrest (Mega-ROX HIE).
Crit Care Resusc
June 2024
Article Synopsis
- - The
- Mega-ROX HIE trial
- is an international study designed to compare conservative versus liberal oxygen therapy in adults with hypoxic ischaemic encephalopathy (HIE) after cardiac arrest who are on mechanical ventilation in ICU settings.
- - The
- trial aims to enroll around 4,000 participants
- and will measure all-cause mortality within 90 days from randomization as its primary outcome, alongside several secondary outcomes related to survival and hospital stay.
- - The study is structured to reduce any potential analysis bias by clearly outlining its
- protocol and statistical analysis plan
- , and aims to provide insights into effective oxygen therapies for this population.
Background: The prevalence of autoimmune conditions is two-fold higher in women than in men, especially during the reproductive years. Autoimmune conditions have been associated with a greater risk of adverse pregnancy outcomes, and some conditions have been studied more than others with inconsistent findings. The objective of this umbrella review was to identify, appraise, synthesise, and consolidate findings from published systematic reviews of autoimmune conditions and adverse pregnancy outcomes.
View Article and Find Full Text PDFProtocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains).
Crit Care Resusc
March 2023
Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults who have nonhypoxic ischaemic encephalopathy acute brain injuries and conditions and are receiving invasive mechanical ventilation in the intensive care unit (ICU) is uncertain.
Objective: The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Brains trial.
Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with sepsis in the intensive care unit (Mega-ROX Sepsis).
Crit Care Resusc
June 2023
Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults with sepsis receiving unplanned invasive mechanical ventilation in the intensive care unit (ICU) is uncertain.
Objective: The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Sepsis trial.