The Effect of Centella asiatica Methanolic Extract on Expression of IL-1β Proinflammatory Cytokines in Severe Early Childhood Caries.

Objective:  This article analyzes the role of extract in reducing the proinflammatory cytokine interleukin (IL)-1β produced by salivary neutrophils.

Material And Methods:  Selected kindergartens in the Surabaya area provided samples. The sample was initially checked for dental caries by measuring its def-t index, and then the participants who satisfied the requirements for severe caries with a def-t of greater than 6 were chosen.