Publications by authors named "Fatemeh Zaeimi"
Background: The 2018 ASCO pleural mesothelioma (PM) treatment guideline states that "a trial of expectant observation may be offered" in patients with asymptomatic inoperable epithelioid mesothelioma with low disease burden. The aim of our analysis was to evaluate clinical characteristics and outcomes in PM-patients managed with initial observation and deferred treatment initiation.
Methods: We retrospectively collected clinicodemograhic and outcome data of patients with inoperable PM.
Article Synopsis
- * A study used multiomic analysis to show that MESO EMT genes correlated with epigenetic changes (like hypermethylation) and a decline in specific tumor-suppressor gene expressions (CDKN2A/B).
- * The expression of these MESO EMT genes was connected to reduced responses from immune markers (IFN-α and IFN-γ) and increased expression of immune checkpoints (like PD-L1 and PD-1), indicating a potential mechanism for immune evasion and poor therapeutic
Background: Overall survival (OS) for malignant pleural mesothelioma (MPM) in vulnerable subgroups remains poorly understood with scarce data available to guide treatment decisions. The study describes real-world detailed treatment patterns and outcomes of patients with advanced MPM overall and specifically in elderly and poor performance status (PS) patients.
Methods: Retrospective chart review was performed for all patients with histologically confirmed MPM seen at University Health Network/Princess Margaret Cancer Centre (UHN-PM).