Hand-foot syndrome (HFS) is a common and painful side effect of chemotherapy that may require limiting doses, but topical celecoxib has shown promise as a safer alternative to oral administration.
A 1% celecoxib hydrogel was created and tested for its effectiveness in treating HFS in cancer patients, showing good stability and skin retention in preliminary studies.
In a trial with 29 participants, significant improvements were observed in HFS symptoms after using the celecoxib hydrogel compared to a placebo, indicating its potential as a treatment option.