Publications by authors named "Fatemeh Rabiei"

Article Synopsis
  • Impaired mitochondrial function significantly contributes to the development of neurodegenerative diseases by releasing substances that activate the NLRP3 inflammasome, a key player in neuroinflammation.
  • *The activation of the NLRP3 inflammasome is linked to a variety of neurodegenerative conditions, including Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, ALS, and Friedrich ataxia.
  • *The review emphasizes potential therapeutic strategies focused on targeting the inflammasome and its signaling pathways to help alleviate symptoms and slow down disease progression.*
View Article and Find Full Text PDF

Introduction/objective: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression.

View Article and Find Full Text PDF

Multiple sclerosis (MS) is a chronic central nervous system (CNS) disorder characterized by demyelination, neuronal damage, and oligodendrocyte depletion. Reliable biomarkers are essential for early diagnosis and disease management. Emerging research highlights the role of mitochondrial dysfunction and oxidative stress in CNS disorders, including MS, in which mitochondria are central to the degenerative process.

View Article and Find Full Text PDF

Purpose: The BMPR1B and BMP15 genes are well known for their considerable associations with prolificacy in sheep. These genes may also affect fertility or prolificacy in other species, including human. This study was conducted to investigate possible causative mutations in BMPR1B and BMP15 genes in human and an indigenous breed of sheep.

View Article and Find Full Text PDF

Understanding the transmission pathways of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will aid in developing effective therapies directed at the virus's life cycle or its side effects. While severe respiratory distress is the most common symptom of a coronavirus 2019 (COVID-19) infection, the virus is also known to cause damage to almost every major organ and system in the body. However, it is not obvious whether pathological changes in extra-respiratory organs are caused by direct infection, indirect, or combination of these effects.

View Article and Find Full Text PDF