C-Kit progenitors restore rat asthmatic lung function by modulation of T-bet and GATA-3 expression.

New Findings: What is the central question of this study? The aim of the experiment was to highlight the regenerative capacity of bone marrow Kit cells in the restoration of asthmatic pulmonary function in the rat model. What is the main finding and its importance? Data showed that these cells were recruited successfully to the asthmatic niche after intratracheal administration and accelerated the regeneration of asthmatic lungs by the modulation of inflammation via the control of Gata3 and Tbx21 expression, leading to decreased tracheal responsiveness to methacholine and reduction of pathological remodelling.

Abstract: Allergic asthma is a T helper (Th) 2 immunological disorder with consequential uncontrolled inflammatory responses.