Publications by authors named "Fatemeh Maghsood Ahmadi"
Simultaneous targeting of several mutations can be useful in colorectal cancer (CRC) due to its heterogeneity and presence of somatic mutations. As CT26 mutations and expression profiles resemble those of human CRC, we focused on designing a polyepitope vaccine based on CT26 neoepitopes. Due to its low immunogenicity, outer membrane vesicles (rOMV) as an antigen delivery system and adjuvant was applied.
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- Outer membrane vesicles (OMVs) are nanoparticles produced by gram-negative bacteria, classified into native (nOMVs) and non-native (dOMVs) based on their production methods.
- OMVs can effectively induce immune responses and have become valuable in biomedical applications, including vaccines for infections and cancer therapy.
- Various factors like growth conditions, genetic modifications, and stressors can influence OMV production, and recent research explores their use as adjuvants, drug delivery systems, and enzyme carriers.