Publications by authors named "Fatemeh Khoshtale"
Article Synopsis
- A new series of coumarin derivatives linked to benzyl triazole was synthesized and tested for their effectiveness against enzymes related to Alzheimer's disease, specifically 15-lipoxygenase and cholinesterases.
- While most of these compounds showed only weak to moderate effects, some standouts exhibited strong neuroprotective properties, outperforming the standard drug quercetin in cell models.
- Further studies, including docking and kinetic analysis, indicated that the top-performing compounds could be promising candidates for future development in treating Alzheimer's disease, due to their solid inhibition of targeted enzymes and prevention of amyloid aggregation.
