Publications by Fatemeh Karimi Madab

Publications by authors named "Fatemeh Karimi Madab"

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Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity.

Valiollah Hajhashemi Hossein Sadeghi Fatemeh Karimi Madab

Korean J Pain

January 2024

Background: Sitagliptin is an antidiabetic drug that inhibits dipeptidyl peptidase-4 enzyme. This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin in formalin and carrageenan tests and determine the possible mechanism(s) of its antinociceptive activity.

Methods: Male Swiss mice (25-30 g) and male Wistar rats (180-220 g) were used for formalin and carrageenan tests, respectively.

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- Fatemeh Karimi Madab's recent research focuses on the pharmacological effects of sitagliptin, an antidiabetic medication, particularly its anti-inflammatory and antinociceptive properties in animal models.
- The study employs both formalin and carrageenan tests using male Swiss mice and male Wistar rats to assess the drug's effects on pain and inflammation.
- Findings suggest that sitagliptin may possess significant antinociceptive activity, shedding light on possible mechanisms involved that could contribute to its therapeutic applications beyond diabetes management.

Publications by authors named "Fatemeh Karimi Madab"

Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity.

Synopsis of recent research by authors named "Fatemeh Karimi Madab"