Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review.

Introduction: Erectile dysfunction (ED) is a substantial cause of dissatisfaction among many men. This discontentment has led to the emergence of various drug treatment options for this problem.

Objectives: Unfortunately, due to various interactions, contraindications, and side effects, systemic therapies such as phosphodiesterase-5 inhibitors (including sildenafil, tadalafil, vardenafil, avanafil, etc.

Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review.

Introduction: Erectile dysfunction (ED) is a substantial cause of dissatisfaction among many men. This discontentment has led to the emergence of various drug treatment options for this problem.

Objectives: Unfortunately, due to various interactions, contraindications, and side effects, systemic therapies such as phosphodiesterase-5 inhibitors (including sildenafil, tadalafil, vardenafil, avanafil, etc.

Laser Ablation-Assisted Synthesis of Poly (Vinylidene Fluoride)/Au Nanocomposites: Crystalline Phase and Micromechanical Finite Element Analysis.

In this research, piezoelectric polymer nanocomposite films were produced through solution mixing of laser-synthesized Au nanoparticles in poly (vinylidene fluoride) (PVDF) matrix. Synthetization of Au nanoparticles was carried out by laser ablation in -methyle-2-pyrrolidene (NMP), and then it was added to PVDF: NMP solution with three different concentrations. Fourier transformed infrared spectroscopy (FTIR) and X-ray diffraction (XRD) were carried out in order to study the crystalline structure of the nanocomposite films.

Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea.

Objective: Primary dysmenorrhea is one of the most commonly reported disorders for women that have unfavorable effects on patient's quality of life. Based on the evidences that suggest the anti-inflammatory and analgesic properties of chlorella, this double-blind, randomized, placebo controlled clinical trial aimed to evaluate the effects of Chlorella supplementation on the severity of menstrual pain in a group of young women with primary dysmenorrhea.

Study Design: In this clinical trial, 44 girls with primary dysmenorrhea were randomly divided into intervention and control groups.

Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial.

Elevated levels of reactive oxygen species under diabetic condition lead to vascular complications and inflammation. This study aimed to examine the effects of hesperidin supplement on blood pressure and inflammatory markers in type 2 diabetes. In this research, 64 patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks.

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

This study aimed to examine the effects of hesperidin supplement on the glycemic parameters, oxidative DNA damage, and lipid peroxidation in patients with type 2 diabetes. Sixty-four patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on glycemic parameters, total antioxidant capacity (TAC), 8-hydroxydeoxyguanosine (8-OHDG), and malondialdehyde (MDA) were collected at the baseline and at the end of the study.

Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.

Aim: The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes.

Materials And Methods: In this randomized, double-blind, placebo-controlled clinical trial, 75 type 2 diabetes patients were assigned to three treatment groups, receiving one of the following daily supplement for 4 months: Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg); Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg), biotin (200 μg), B12 (10 μg) and folic acid (1 mg); Group P: placebo.

Results: 67 patients completed the study.