Vascular endothelial cells play a vital role in the health and maintenance of vascular homeostasis, but hyperglycemia disrupts their function by increasing cellular oxidative stress. Resveratrol, a plant polyphenol, possesses antioxidant properties that can mitigate oxidative stress. Addressing the challenges of its limited solubility and stability, gold nanoparticles (GNps) were utilized as carriers.
View Article and Find Full Text PDFOxidation of starch is one of the most commonly used approaches to improve its properties in the thermoplastic (TP) reactions. Iron oxide nanoparticle (IONP) (8.2 ± 1.
View Article and Find Full Text PDFThis study investigates the effect of the nanostructure of squalene in the form of microemulsion on COVID-19 patients. In this blinded clinical trial, a comparison was made between the efficacy of squalene treatment and controls. A total of 30 COVID-19 patients admitted to the emergency department, and the infection ward was equally allocated to case (n = 15) and control (n = 15) groups according to their age and underlying diseases.
View Article and Find Full Text PDFPurpose: Intraoperative radiotherapy (IORT) technique is an advanced radio therapeutic method used for delivery of a single high-dose radiation during surgery while removing healthy tissues from the radiation field. Nowadays, growing attention is being paid to IORT for its low-energy (kilovoltage) delivery as it requires less radiation protection, but suffers several disadvantages, including high-dose delivery and prolonged treatment time. The application of nanoparticles with high atomic number and high attenuation coefficients in kilovoltage energy may help overcome the mentioned shortcomings.
View Article and Find Full Text PDFPhototherapy is a minimally invasive oncological treatment strategy in which photon energy is delivered to the tumor tissue. Gold nanoparticles (GNPs) can enhance photothermal or photodynamic phenomena when excited by a wavelength beam in the range of UV-IR. GNPs are used in phototherapy for cancer cell treatment by controlling the physical and chemical conditions.
View Article and Find Full Text PDFIron oxide nanoparticles (IONs) have several applications in medical fields including magnetic resonance imaging (MRI), drug delivery, cancer treatment and cell splitting. Therefore, it is important to investigate their cellular toxicity. It is difficult to predict their cellular toxicity due to complexities associated with their cellular mechanisms.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
September 2018
Background: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). After identifying specifications and cytotoxicity of the agents, the potential of SGI for photodynamic therapy (PDT) and photothermal therapy (PTT) was studied.
Methods: An SGI size of 12-13 nm was determined by TEM images and its zeta potential was measured at -23.