-5,15-Bis[3-(iso-propyl-idenegalacto-pyran-oxy)phen-yl]-10,20-bis-(4-methyl-phen-yl)porphyrin.

The crystal structure of a glycosyl-ated porphyrin () system, CHNO, where two iso-propyl-idene protected galactose moieties are attached to the position of a substituted tetra-aryl porphyrin is reported. This structure reveals that the parent porphyrin is planar, with the galactose moieties positioned above and below the porphyrin macrocycle. This orientation likely prevents porphyrin-porphyrin H-type aggregation, potentially enhancing its efficiency as a photosensitizer in photodynamic therapy.

Structural insights into 1,4-bis-(neopent-yloxy)pillar[5]arene and the pyridine host-guest system.

The crystal structure of 1,4-bis-(neopent-yloxy)pillar[5]arene, CHNO (, featuring two encapsulated pyridine mol-ecules, reveals significant host-guest inter-actions. Inter-estingly, the pyridine guests are positioned near the neopent-yloxy substituents instead of the electron-rich aromatic core of the pillar[5]arene. This spatial arrangement suggests a preference for the pyridine mol-ecules to engage with the aliphatic regions of the host.

Crystal structure and supra-molecular features of a bis-urea-functionalized pillar[5]arene.

The crystal structure of a bis-urea derivative based on A1/A2-functionalized pillar[5]arene () that encapsulates dimethyl formamide () inside the macrocyclic cavity is reported. The crystal structure of , CHNO·CHNO, reveals that out of two urea functionalized spacers, one arm is oriented above the macrocyclic cavity with strong hydrogen-bonding inter-actions between the urea H atoms and guest, whereas, the other arm is positioned away from the macrocycle, leading to inter-molecular hydrogen-bonding inter-actions between the urea H atoms of two adjacent pillar[5]arene macrocycles, resulting in the formation of a supra-molecular dimer.

Spatially Designed Supramolecular Anion Receptors Based on Pillar[5]arene Scaffolds: Synthesis and Halide Anion Binding Properties.

Urea-functionalized anion receptors based on brominated functionalized pillar[5]arenes were prepared. The binding affinity toward halide anions was investigated and probed using H NMR titration and isothermal titration calorimetry (ITC). The complexation behavior was affected by the structure of the receptor and the nature of the anionic guest.

Synthesis, functionalization, and isolation of planar-chiral pillar[5]arenes with bulky substituents using a chiral derivatization agent.

Bulky perneopentyloxy-pillar[5]arene (Pillar-1) was synthesized and its conformational mobility was investigated using variable-temperature H NMR spectroscopy. The host-guest interactions between Pillar-1 and -octyltrimethylammonium hexafluorophosphate (OMA) were investigated, and the formation of a 1 : 1 complex was revealed H NMR. Planar-chiral isomers were synthesized the reaction of a hydroxy-functionalized pillar[5]arene with chiral derivatization agent ()-(+)-MTPA-Cl.

Constitutional isomers of brominated-functionalized copillar[5]arenes: synthesis, characterization, and crystal structures.

We herein report the preparation of constitutional isomers of brominated-functionalized pillar[5]arenes co-condensation of 1,4-bis(2-bromoethoxy)benzene and 1,4-dimethoxybenzene. The structures of the obtained isomers were then established using single crystal X-ray diffraction. We also found that the isomeric yield distribution of the different constitutional isomers was independent of the monomer's mole feed ratio, as revealed by HPLC analysis of the crude mixture.

Encapsulated di-chloro-ethane-mediated inter-locked supra-molecular polymeric assembly of A1/A2-dihydroxy-oct-yloxy pillar[5]arene 1,2-di-chloro-ethane monosolvate.

Crystals of 1-(1,4-dihy-droxy)-2,3,4,5-(1,4-dioct-yloxy)-pillar[5]arene, CHO·CHCl, were grown from a 1,2-dicholoro-ethane/-hexane solvent system. In the crystal, the encapsulated 1,2-di-chloro-ethane solvent is stabilized by C-H⋯π inter-actions and mediates the formation of an inter-locked supra-molecular polymer C-H⋯Cl inter-actions.

An alternative route for the synthesis of hydroxylated pillar[5]arene-based amphiphiles.

Conformational mobilities of the units and host-guest complexation with n-octyltrimethylammonium hexafluorophosphate of the synthesized perbenzylated pillar[5]arenes were studied. The formed complex was confirmed by proton nuclear magnetic resonance spectroscopy and mass spectral analysis. Hydroxylated pillar[5]arene-based amphiphiles were synthesized by a co-cyclization strategy followed by catalytic hydrogenation.

Single-crystal X-ray diffraction study of a host-guest system comprising monofunctionalized-hydroxy pillar[5]arene and 1-octa-namine.

Co-crystallization of a monofunctionalized hy-droxy pillar[5]arene with 1-octa-namine resulted in the formation of an inclusion complex where the alkyl chain is threaded in the macrocycle cavity, namely 1,2,3,4-(1,4-dimeth-oxy)-5-(1-hy-droxy-4-meth-oxy)-pillar[5]arene-1-octa-namine-water (1/1/1), CHO·CHN·HO. The guest compound is stabilized inside the cavity by hydrogen-bonding and C-H⋯π inter-actions. The water mol-ecule in the asymmetric unit mediates the formation of a supra-molecular dimer by hydrogen-bonding inter-actions.

Constitutional Isomers of Pentahydroxy-Functionalized Pillar[5]arenes: Synthesis, Characterization, and Crystal Structures.

We herein report the preparation of constitutional isomers of pentahydroxy-functionalized pillar[5]arenes via the deprotection of their benzylated derivatives by catalytic hydrogenation. The structures of the obtained isomers were then established using single crystal X-ray diffraction. We also found that the yield distribution of the different constitutional isomers was dependent on the nature of the substitution, as revealed by HPLC analysis of the crude mixture.

Molecular assemblies of porphyrins and macrocyclic receptors: recent developments in their synthesis and applications.

Metalloporphyrins which form the core of many bioenzymes and natural light harvesting or electron transport systems, exhibit a variety of selective functional properties depending on the state and surroundings with which they exist in biological systems. The specificity and ease with which they function in each of their bio-functions appear to be largely governed by the nature and disposition of the protein globule around the porphyrin reaction center. Synthetic porphyrin frameworks confined within or around a pre-organized molecular entity like the protein network in natural systems have attracted considerable attraction, especially in the field of biomimetic reactions.