Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression.

The high incidence rate coupled with significant mortality makes colorectal cancer one of the most prevalent and devastating cancers worldwide. Research is currently underway to explore new forms of treatment that could potentially maximize treatment outcomes while minimizing the side effects associated with conventional chemotherapy. Metformin, a natural biguanide drug, has anti-cancer properties that can inhibit the growth and proliferation of cancer cells.

Nonsurgical Management of a Large Periapical Lesion: A Case Report.

This case report describes the non-surgical management of a large cyst-like periapical lesion in the mandible of a 16-year-old female with the chief complaint of periodic swelling and pus drainage from the mandibular anterior region gingivae with no history of pain and traumatic accident in this area. Both mandibular central incisors had extensive caries. Root canals of both mandibular central incisors were filled with calcium hydroxide.

Watching television by kids: How much and why?

Introduction: Television (TV) viewing by children may be linked to a range of adverse health and behavioral outcomes. This study was aimed at examining the relationship between socioeconomic factors of families and TV watching behavior among 3-5 years old children in Ardakan, Yazd, Iran.

Materials And Methods: In the cross-sectional study, mothers of 188 children (93 boys and 95 girls) between 3 and 5 years old completed a researcher-designed questionnaire.