Effects of metformin and curcumin in women with polycystic ovary syndrome: A factorial clinical trial.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, associated with dyslipidemia, insulin resistance, and hormonal imbalances. Metformin and curcumin have shown promise in improving these metabolic and hormonal parameters individually, but their combined effects in PCOS remain unclear.

Methods: We conducted a randomized, double-blind, placebo-controlled, 12-week factorial trial involving 200 women with PCOS.

Mechanical characterization of reinforced vertically-aligned carbon nanotube array synthesized by shock-induced partial phase transition: insight from molecular dynamics simulations.

Despite intriguing mechanical properties of carbon nanotubes (CNTs), vertically-aligned carbon nanotube (VACNT) array does not possess a high strength against compression along the CNT axis and also the loadings perpendicular to the CNT axis. Here in this study, shock compression is introduced as a means for partial phase transition (PPT) in the VACNT array to reinforce the structure against the mentioned loadings. Molecular dynamics simulations are exploited to investigate the synthesis of a novel nanostructure from a VACNT array with 10 nm long (5, 5) CNTs.