Publications by authors named "Fatemeh Babajani"
Article Synopsis
- The study examines the relationship between specific genetic variations (polymorphisms) in matrix metalloproteinases MMP-2 and MMP-9 and the occurrence of aortic valve calcification (AVC) in individuals.
- It involved 92 AVC patients and 92 healthy individuals from western Iran, using various methods to analyze gene variations and the serum levels of these enzymes.
- Results indicated that AVC patients had higher frequencies of risk alleles (A for MMP-2 and T for MMP-9) and elevated levels of MMP-2 and MMP-9 compared to healthy controls, suggesting a link between these factors and increased cardiovascular disease risk.
Purpose: Oxidative stress in chronic hyperglycemia could injure the tissues and onset of diabetes-related complications like retinopathy and neuropathy. This study investigates the association between methylenetetrahydrofolate reductase (MTHFR) and glutathione peroxidase (GPx) genetic variants with these complications.
Methods: In this case-control study, 400 individuals, including 100 healthy subjects and 300 patients with type 2 diabetes mellitus (T2DM) in three subgroups: with retinopathy(n = 100), with neuropathy(n = 100), and without complication (n = 100) from West Iran, were studied.
Aims: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the ACE2 component of the renin-angiotensin aldosterone system (RAAS) and infects the human cells. The aims of the present review were to look at the role and alteration of the RAAS components in SARS-CoV-2 infection, therapeutic approaches, and clinical trials in this field.
Methods: We surveyed the literature (PubMed, Web of Science, and Scopus) till August 18, 2021, and 59 published papers regarding the components of the RAAS and their role and alterations in SARS-CoV-2 infection along with various COVID-19 therapies based on the RASS components were included in the study.