Cross-Dehydrogenative C-H/S-H Coupling Reactions.

Carbon-sulfur bond formation represents a key step in the synthesis of thioethers, which are a common structural motif in many pharmaceutically compounds. The direct cross-dehydrogenative coupling of C-H/S-H bonds has become a powerful tool for C-S bond formation. As these coupling reactions avoid pre-functionalization of the starting materials, they are more atom-economical, practical, and environmentally friendly than traditional cross-coupling reactions.

Decarboxylative cross-coupling reactions for P(O)-C bond formation.

Phosphorus-containing compounds are one of the most important classes of organic compounds, which have wide applications in organic chemistry, medicinal chemistry, agricultural chemistry, and materials chemistry. In particular, organophosphorus compounds bearing a P(O)-C bond have attracted significant attention in recent decades due to their widespread biological and pharmacological activities. In this review, we will highlight the most important developments in the construction of P(O)-C bonds through decarboxylative C-P cross-coupling reactions.

Recent advances in sulfur-nitrogen bond formation cross-dehydrogenative coupling reactions.

This focus-review surveys literature methods for the construction of sulfur-nitrogen bonds through cross-dehydrogenative coupling reactions between thiols and N-H compounds with a particular emphasis on the mechanistic aspects of the reactions. The literature has been surveyed until the end of 2017.