Publications by authors named "Fatemeh Alimohammadi"
Restricting amino acids from tumors is an emerging therapeutic strategy with significant promise. While typically considered an intracellular antioxidant with tumor-promoting capabilities, glutathione (GSH) is a tripeptide of cysteine, glutamate, and glycine that can be catabolized, yielding amino acids. The extent to which GSH-derived amino acids are essential to cancers is unclear.
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- Cells depend on antioxidants like glutathione (GSH) for survival, with its production controlled by the enzyme GCLC.
- GSH is crucial for maintaining lipid levels in the liver, a key site for lipid production, and its deficiency affects fat storage and triglyceride levels.
- The study reveals that GSH influences lipid abundance by regulating the transcription factor NRF2, linking antioxidant function to lipid metabolism.
Within a cell, proteins have distinct and highly variable half-lives. As a result, the molecular ages of proteins can range from seconds to years. How the age of a protein influences its environmental interactions is a largely unexplored area of biology.
View Article and Find Full Text PDFScientists in this field often joke, "If you don't have a mechanism, say it's ROS." Seemingly connected to every biological process ever described, reactive oxygen species (ROS) have numerous pleiotropic roles in physiology and disease. In some contexts, ROS act as secondary messengers, controlling a variety of signaling cascades.
View Article and Find Full Text PDFArticle Synopsis
- - Cells depend on antioxidants like glutathione (GSH) for survival, with GSH being the most abundant antioxidant regulated by the enzyme GCLC.
- - A study involving the deletion of GSH in adult animals revealed its crucial role in maintaining lipid levels, particularly in the liver, which is key for lipid production.
- - The absence of GSH led to decreased expression of lipogenic enzymes, lower triglyceride levels, and reduced fat stores, highlighting GSH's role in balancing oxidative stress and lipid production through the repression of the transcription factor NRF2.
The dpy-19 like 2 (DPY19L2) gene is the most common genetic cause of globozoospermia characterised by the production of round-headed spermatozoa without an acrosome. The present study was performed on 63 men with globozoospermia and 41 normozoospermic individuals to evaluate the frequency of the DPY19L2 gene and exons; deletion and genetic changes in exons 1, 5, 7-11, 19, 21 and interval introns; and some epidemiological factors (e.g.
View Article and Find Full Text PDFThe dpy-19 like 2 (DPY19L2) gene is the most common genetic cause of globozoospermia characterised by the production of round-headed spermatozoa without an acrosome. The present study was performed on 63 men with globozoospermia and 41 normozoospermic individuals to evaluate the frequency of the DPY19L2 gene and exons; deletion and genetic changes in exons 1, 5, 7-11, 19, 21 and interval introns; and some epidemiological factors (e.g.
View Article and Find Full Text PDFIntroduction: Upper trapezius trigger points are among the most common causes of neck pain. This study aimed to investigate the effects of integrated Neuromuscular Inhibition Technique (INIT) on pain intensity and threshold.
Materials & Methods: Thirty two female participants with upper trapezius trigger points were recruited in this study.