An Overview of Radiolabeled RGD Peptides for Theranostic Applications.

Angiogenesis phenomenon, as a highly affecting factor on the growth and spread of cancer cells, depends on specific molecular interactions between components of the extracellular matrix and vascular cells. αv integrin acts as a cell adhesive molecule involved in tumor invasion and angiogenesis. Among the various combinations of integrin subunits expressed on the surface of cells, αβ integrin has a particularly interesting expression pattern during angiogenesis.