Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer.

Introduction: Persistent Human Papillomavirus (HPV) infection is linked to 99% of cervical cancer (CC) cases. HPV types 16 and 18 alone result in 75% of CC cases and thus are considered to be high-risk types (HR-HPV). CC is the third most common cancer among women globally.

Impact of Weight Loss on the Severity of Albuminuria in Obese Diabetic Patients Undergoing Laparoscopic Sleeve Gastrectomy and One-Anastomosis Gastric Bypass.

Aim: To examine the effect of weight-loss induced bariatric procedures on albuminuria levels among diabetic patients suffering from obesity.

Methods: Adults patients who suffer from morbid obesity and type 2 diabetes mellitus (T2DM) were included in a prospective cohort study. Subjects were scheduled to undergo laparoscopic sleeve gastrectomy (LSG) or one-anastomosis gastric bypass (OAGB).

Synthesis, structure, and electrochemical properties of [LNi(R)(CF)] and [LNi(R)] complexes.

The new anionic nickelate complexes [(MeCN)Ni(CF)(CF)], [(MeCN)Ni(CF)(CF)], [(IMes)Ni(CF)(CF)], [(IMes)Ni(CF)] (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene), and [(F-NHC)Ni(R)] (F-NHC = 1,3-bis(2,4-FPh), 2,4,6-FPh- or 3,4,5-FPh)imidazol-2-ylidene; (R = CF or CF) were synthesized and structurally characterized. The electrochemical properties of all new compounds were revealed by cyclic voltammetry studies and compared to the known CF analogue [(MeCN)Ni(CF)]. The IMes-coordinated complexes exhibited initial oxidation events that were well-separated from a second oxidation process in the cyclic voltammograms.

Altered prefrontal cortical metabolic response to mesocortical activation in adult animals with a neonatal ventral hippocampal lesion.

Background: Adult animals with a neonatal ventral hippocampal lesion (NVHL) exhibit deficits in working memory and sensorimotor gating similar to those observed in schizophrenia. As cognitive deficits in this disorder are typically associated with changes in cortical metabolic levels, we investigated here whether an NVHL affects metabolic responses to ventral tegmental area (VTA) activation, a procedure that elicits abnormal cell firing in the prefrontal cortex (PFC) of NVHL animals.

Methods: Prefrontal cortex metabolic activity was determined by measuring cytochrome oxidase I (CO-I) staining.