Study on preparation, compression strength and theophylline/diclofenac sodium release ability of NIPAAm/DMAPMAAm hydrogels.

The present study was undertaken to investigate the effect of the composition of the polymerization medium and the type of drug/drug loading process on the mechanical strengths and release profiles of poly(N-isopropylacrylamide-co-N-[3-(dimethylamino)propyl] methacrylamide) P(NIPAAm-co-DMAPMAAm) hydrogels. In line with this goal firstly, the temperature- and pH-responsive hydrogels of NIPAAm and DMAPMAAm were synthesized in three different media at 60 °C: pH 7.4 phosphate-buffered saline (PBS), pH 7.